Evidence map›Paper›PMID 39950936›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Selenium Electrophilic Center Responsive to Biological Electron Donors for Efficient Chemotherapy.

Xiaoyu Qin, Junxian Guo, Hui Li, Hanlong He, Fei Cai, Xinyan Chen, Mingkai Chen, Tianfeng Chen, Li Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Selenium-Based Nanoplatforms: An Emerging Theranostic Paradigm for Gynecological Cancers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoyu QinDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Junxian GuoDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Hui LiDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Hanlong HeDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Fei CaiDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Xinyan ChenDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Mingkai ChenDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.
Tianfeng ChenDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.ORCID https://orcid.org/0000-0001-6953-1342
Li MaDepartment of Pharmacy and General Surgery of Puning People's Hospital (Guangdong Postdoctoral Innovation Practice Base of Jinan University), College of Chemistry and Materials Science, State Key Laboratory of Bioactive Molecules and Druggability Assessment, MOE Key Laboratory of Tumor Molecular Biology, Guangdong Provincial Key Laboratory of Spine and Spinal Cord Reconstruction, Jinan University, Guangzhou, 510632, China.

Funding

China National Postdoctoral Program for Innovative Talent BX20240141National Natural Science Foundation of China 21877049National Natural Science Foundation of China 22177038National Natural Science Foundation of China 32171296National Natural Science Foundation of China 82372103National Science Fund for Distinguished Young Scholars 82225025
6 · The paper itself

Abstract

Designing drugs to intelligently respond to different ratio of biological electron donors/receptors in cancer cells and normal cells is a promising strategy to achieve highly effective and less toxic chemotherapy. Herein by employing metal center to active the selenium-containing electrophilic center drug Ru(phtpy-NO

Indexed as

Antineoplastic AgentsNeoplasmsSeleniumCell Line, TumorDNA DamageElectronsElectron TransportHumansMembrane Potential, MitochondrialOxidative StressAntineoplastic AgentsSeleniumbiological electron donorscellular energeticelectrophilic centerselenium atom

Identifiers

PMID39950936
PMCPMC11984860

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.