ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Unlocking Long-Lived Charge-Separated State in Pentamethine Cyanine Based on Anionic Hofmeister Effect for Photodynamic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Strengthening D-A Push-Pull Interactions in BODIPY to Enhance Near-Infrared Absorption and Photothermal Conversion for Low-Intensity Photothermal Antitumor Therapy.Molecules (Basel, Switzerland) · 2026Article
- Recent advances of cyanine dyes in tumor theranostics: molecular modification, delivery strategies, and synergistic mechanisms.RSC advances · 2026Review
- Deprotonation- and TICT-triggered ultra-large Stokes shift of aqueous NIR-emissive hydroxylstryryl-pyridinium derivatives.RSC advances · 2026Article
- Electrostatic Co-Assembly of Cyanine Pair for Augmented Photoacoustic Imaging and Photothermal Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Excited-State-Altering Ratiometric Fluorescent Probes for the Response ofMolecules (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Molecular phototheranostic dyes are of eminent interest for oncological diagnosis and imaging-guided phototherapy. However, it remains challenging to develop photosensitizers (PSs) that simultaneously integrate high-contrast photoacoustic imaging and efficient therapeutic capabilities. In this work, a supramolecular strategy is employed to construct a molecular pair phototheranostic agent via the direct self-assembly of two cyanines, C5TNa (anionic) and Cy-Et (cationic). The Coulombic interactions between C5TNa and Cy-Et facilitate the formation of a complementary cyanine pair (C5T-ET) and the creation of supramolecular CT-J-type aggregates in water. This complementary cyanine pair (C5T-ET) results in completely quenched fluorescence and significantly enhances nonradiative deactivation (≈22 ps), leading to a 3.3-fold increase in photothermal conversion efficiency and a 7.1-fold enhancement in photoacoustic response compared to indocyanine green (ICG). As a result, the J-type aggregate cyanine pair (C5T-ET) demonstrates high photoacoustic imaging capability and remarkable antitumor phototheranostic efficacy in vivo, highlighting its potential for clinical applications. This work provides strong experimental evidence for the superior performance of the complementary cyanine pair (C5T-ET) in enhancing photosensitization and photoacoustic response. It is believed that this strategy will propel the advancement of controllable dye J-aggregates and contribute to the practical implementation of photoacoustic imaging and phototherapy in vivo.
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