ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Advances in Electrical Materials for Bone and Cartilage Regeneration: Developments, Challenges, and Perspectives.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- A motion-activated skeletal "Pacemaker" for systemic bone remodeling via oral piezoelectric microspheres.Bioactive materials · 2026Article
- An Injectable and Self-Reinforced Piezoelectric Hydrogel for Irregular Bone Defects Regeneration: Dynamic Epigenetic Regulation Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Intratumoral therapeutic dust for chemo-photodynamic combination treatment.Science advances · 2026Article
- In situ-built chemo-electroactive hydrogel incorporating Mg-based hydrogen generators for osteoarthritis therapy.Materials today. Bio · 2026Article
- 3D-Printed biodegradable and multifunctional cranial device for bone repair and healing assessment.Science advances · 2026Article
- Evolutionary applications of electrical stimulation in bone repair: bibliometric trends and temporal dynamics.EFORT open reviews · 2026Review
- Chondrocytes in fracture healing: A review of chondrocyte journey.Chinese medical journal · 2026Review
- Biophysical signal-driven scaffold design for stem cell-guided osteochondral regeneration.Bioactive materials · 2026Review
- Mechanically-driven expandable patch promotes tracheal defect reconstruction via synergistic microcurrent and mechanical force cascades.Nature communications · 2026Article
- Exploring the piezoelectric phenomenon: From polymers to human tissues and advanced applications in tissue engineering.Bioactive materials · 2026Review
- Vibration or Stretch? Distinct Mechanoelectrical Signatures Govern Osteogenic Programming in PVDF.ACS applied materials & interfaces · 2026Article
- Piezoelectric scaffold with enhanced effect drives the healing of osteochondral defects through electromechanical-immune coupling.Journal of nanobiotechnology · 2026Article
- The application of tissue engineering in cartilage regeneration: technological advances and future challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Harnessing piezoelectricity for bone tissue engineering: recapitulating the electrophysiological microenvironment through smart biomaterials.Frontiers in bioengineering and biotechnology · 2026Review
- PEDOTs in Bone Tissue Engineering Composites: Fabrication Strategies and Translational Hurdles.Research (Washington, D.C.) · 2026Review
- Advances in functional nanomaterials and piezoelectric biomaterials for personalized intramedullary fixation: addressing age-related orthopedic challenges.Frontiers in chemistry · 2026Review
- Photodynamic Strategies for Prevention of Titanium Osteoimplant Infections.Research (Washington, D.C.) · 2026Review
- Electrosensitive Heterogeneous Short Fibers via Acousto-Electric Coupling for Sequential Bone Regeneration in Infectious Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.Bioelectronic medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Severe bone and cartilage defects caused by trauma are challenging to treat, often resulting in poor outcomes. An endogenous electric field (EnEF) is crucial for bone regeneration, making electrical materials a promising therapy. This review provides a comprehensive overview of the role of bioelectric signals in bone and cartilage cells, alongside recent advancements in electrical biomaterials, with particular emphasis on nanogenerators, piezoelectric materials, triboelectric scaffolds, and zwitterionic hydrogels. It further investigates the impact of these electrical biomaterials on bone and cartilage regeneration, as well as the applications of both endogenous and exogenous electrical stimulation (ES) and the mechanisms underlying ES-induced cellular and molecular responses. Finally, the review underscores future directions for ES systems in tissue engineering, emphasizing the critical importance of integrating structural integrity, mechanical properties, and electrical signal delivery into intelligent implantable scaffolds.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.