Evidence map›Paper›PMID 39950825›Full record

ArticleMicrobiology spectrum2025

A type-specific B-cell epitope at the apex of outer surface protein C (OspC) of the Lyme disease spirochete,

David J Vance, Grace Freeman-Gallant, Kathleen McCarthy, Carol Lyn Piazza, Yang Chen, Clint Vorauer, Beatrice Muriuki, Michael J Rudolph, Lisa Cavacini, Miklos Guttman and 1 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David J VanceDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-9913-7722
Grace Freeman-GallantDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0009-0003-7154-2763
Kathleen McCarthyDepartment of Biomedical Sciences, University at Albany, Albany, New York, USA.
Carol Lyn PiazzaDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0009-0004-6482-3871
Yang ChenNew York Structural Biology Center, New York, New York, USA.
Clint VorauerDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.
Beatrice MuriukiUniversity of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Michael J RudolphNew York Structural Biology Center, New York, New York, USA.
Lisa CavaciniUniversity of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.ORCID 0000-0003-1417-8339
Miklos GuttmanDepartment of Medicinal Chemistry, University of Washington, Seattle, Washington, USA.ORCID 0000-0003-2419-1334
Nicholas J MantisDivision of Infectious Diseases, Wadsworth Center, New York State Department of Health, Albany, New York, USA.ORCID 0000-0002-5083-8640

Funding

Tickborne Disease: B cell epitope discovery and mechanisms of antibody Protection75N93019C00040 · NIAID · NYSDOH/HEALTH RESEARCH, INC. · PI MANTIS, NICHOLAS J. · 2019 to 2023
$10.3M
Innovations in Functional B Cell Epitope Discovery for Lyme Disease 75N93024C00069 · NIAID · NYSDOH/HEALTH RESEARCH, INC. · PI MANTIS, NICHOLAS · 2024 to 2025
$4.0M
ThermoFisher Scientific Orbitrap Eclipse with ETD and UVPDS10OD030237 · OD · UNIVERSITY OF WASHINGTON · PI GUTTMAN, MIKLOS · 2022 to 2022
$1.2M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 75N93019C00040, 75N93024C00069HHS | NIH | National Institute of General Medical Sciences (NIGMS) S10OD030237NIAID NIH HHS 75N93019C00040NIAID NIH HHS 75N93024C00069NIH HHS S10 OD030237
6 · The paper itself

Abstract

Broadly protective immunity to the Lyme disease spirochete,

Indexed as

Antigens, BacterialBacterial Outer Membrane ProteinsBorrelia burgdorferiEpitopes, B-LymphocyteLyme DiseaseAnimalsAntibodies, BacterialAntibodies, MonoclonalEpitope MappingHumansMiceAntibodies, BacterialAntibodies, MonoclonalAntigens, BacterialBacterial Outer Membrane ProteinsEpitopes, B-LymphocyteOspC proteinantibodyepitopehumanneutralizingvaccine

Identifiers

PMID39950825
PMCPMC11960070

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.