Evidence map›Paper›PMID 39950455›Full record

ArticleMedicinal chemistry (Shariqah (United Arab Emirates))2025

Design, Synthesis, Characterization, and Antitumor Activities of Benzimidazole-functionalized Organoruthenium Complexes Bearing Fluorine Group.

Ramazan Pasahan, Ozlem Demirci, Irmak Icen Taskin, Aziz Pasahan, Meryem Rüveyda Sever, Yetkin Gok, Aydın Aktas

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Article in Medicinal chemistry (Shariqah (United Arab Emirates)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ramazan PasahanDepartment of Neurosurgery, Faculty of Medicine, Inonu University, 44280, Malatya, Türkiye.ORCID 0000-0002-3221-1422
Ozlem DemirciDepartment of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Türkiye.
Irmak Icen TaskinDepartment of Molecular Biology and Genetics, Faculty of Science and Art, Inonu University, Malatya, Türkiye.ORCID 0000-0002-1612-0563
Aziz PasahanHealth Services Vocational School, İnönü University, 44280, Malatya, Türkiye.ORCID 0000-0002-0657-3884
Meryem Rüveyda SeverDepartment of Molecular Biology and Genetics, Faculty of Science and Art, Inonu University, Malatya, Türkiye.ORCID 0000-0001-9271-1528
Yetkin GokDepartment of Chemistry, Faculty of Science, İnönü University, 44280, Malatya, Türkiye.ORCID 0000-0003-3993-7733
Aydın AktasHealth Services Vocational School, İnönü University, 44280, Malatya, Türkiye.ORCID 0000-0001-8496-6782

Funding

İnönü University Research Fund IUBAP TOA-2022-2908
6 · The paper itself

Abstract

backgroundThis work presents the synthesis of Ru(II)NHC complexes bearing a series of 4-fluorobenzyl group. These complexes have been characterized by a variety of spectroscopic methods (

methodsThese complexes' antitumor activities against SH-SY5Y (human neuroblastoma) and

resultsThe results showed that all the synthesized complexes exhibited significant cytotoxic effect with low IC

conclusionFurthermore, apoptosis assessed by double labeling with Annexin V-FITC/PI indicated that complexes 1b and 1d can effectively induce apoptosis and inhibit cell proliferation at the S phase in

Indexed as

Antineoplastic AgentsBenzimidazolesCoordination ComplexesDrug DesignFluorineRutheniumApoptosisCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHCT116 CellsHumansMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsBenzimidazolesCoordination ComplexesFluorineRutheniumAntitumor activitybenzimidazoleDNA bindingN-heterocyclic carbenesorganometallicruthenium.

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.