Evidence map›Paper›PMID 39950404›Full record

ArticleChemistry & biodiversity2025

Phytochemical Characterization and Potential Anti-Oxidative Activity of Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, and cv Super Essential Oils Compared to a Commercial Lavender Essential Oil.

Eileen Mac Sweeney, Ylenia Pieracci, Vlad Sebastian Popescu, Gianluca Angius, Guido Flamini, Luisa Pistelli, Giulia Abate, Andrea Mastinu

Abstract readComparative Study
In one paragraph

Article in Chemistry & biodiversity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pharmaceutical biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eileen Mac SweeneyDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.
Ylenia PieracciDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-0993-7946
Vlad Sebastian PopescuDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0009-0001-8468-6921
Gianluca AngiusDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.
Guido FlaminiDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0003-2418-9349
Luisa PistelliDepartment of Pharmacy, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0000-0002-6898-6510
Giulia AbateDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.
Andrea MastinuDepartment of Molecular and Translational Medicine, Division of Pharmacology, University of Brescia, Brescia, Italy.ORCID https://orcid.org/0000-0002-8862-2896

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigates the phytochemical profiles and antioxidant properties of three lavender essential oils (LEOs) from Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, and Lavandula x intermedia Emeric ex Loisel cv Super, and compares them to a commercial one. LEOs were extracted by hydrodistillation, analyzed using gas chromatography-mass spectrometry, and tested for antioxidant effects on human SH-SY5Y neuroblastoma cells. The major components identified in all the four LEOs were linalool and linalyl acetate; however, in the commercial LEO differences in minor compounds and the presence of additives were found. Antioxidant activity assays revealed significant protection against H₂O₂-induced oxidative stress for hydrodistilled EOs, while the commercial EO showed no protective effect. Gene expression analysis indicated upregulation of antioxidant-related genes in cells treated with "Grosso" and "Super" LEOs. This research highlights the potential therapeutic applications of LEOs, with a particular emphasis on the differences between naturally derived oils and commercial variants.

Indexed as

AntioxidantsLavandulaOils, VolatilePhytochemicalsPlant OilsCell Line, TumorCell SurvivalGas Chromatography-Mass SpectrometryHumansHydrogen PeroxideOxidative StressAntioxidantsHydrogen Peroxidelavender oilOils, VolatilePhytochemicalsPlant Oilsantioxidant activity | GC‐MS | lavender essential oils | oxidative stress

Identifiers

PMID39950404
PMCPMC12270360

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.