Evidence map›Paper›PMID 39950400›Full record

ArticleAdvanced healthcare materials2025

Longer Acting Injectable: Continuous, Linear Release of a Progestin Contraceptive From an Oxidized Porous Silicon Host.

Geoffrey Hollett, Ruhan Fan, Tushar Kumeria, Heidi Leonard, Byungji Kim, Taylor R Martin, Irmak Ipekci, Joanna Wang, Jiuk Byun, Nicole A Chan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Geoffrey HollettMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-2927-0771
Ruhan FanMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0003-0626-849X
Tushar KumeriaSchool of Materials Science and Engineering, University of New South Wales, Kensington, Sydney, NSW, 2052, Australia.ORCID https://orcid.org/0000-0003-3351-7148
Heidi LeonardDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Byungji KimMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0001-8131-5255
Taylor R MartinChien-Lay Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-8431-5047
Irmak IpekciChien-Lay Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Joanna WangMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-3069-124X
Jiuk ByunMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0001-9810-8869
Nicole A ChanDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0003-2508-969X
Amber PierronDepartment of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.
Curtis E MooreDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, OH, 43214, USA.
Jennifer AyresContraceptive Research, Development, and Introduction, FHI 360 359 Blackwell Street, #200, Durham, NC, 27701, USA.
Michael J SailorMaterials Science & Engineering Program, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID https://orcid.org/0000-0002-4809-9826

Funding

Directorate for Mathematical and Physical Sciences DMR-2011924Division of Electrical, Communications and Cyber Systems ECCS-1542148FHI 360 OPP1032101
6 · The paper itself

Abstract

Maintaining stable drug concentrations in the bloodstream is a challenge for injectable hydrophobic progestin contraceptives. This work investigates porous silicon dioxide (pSiO

Indexed as

ProgestinsSiliconSilicon DioxideAnimalsDelayed-Action PreparationsDesogestrelDrug CarriersDrug LiberationFemaleLevonorgestrelOxidation-ReductionPorosityRatsRats, Sprague-DawleyDelayed-Action PreparationsDesogestrelDrug CarriersetonogestrelLevonorgestrelProgestinsSiliconSilicon Dioxidehydrophobic drugsin vivo tolerabilitymelt castingsmicroparticleszero‐order drug releases

Identifiers

PMID39950400
PMCPMC12506854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.