ArticleNucleic acids research2025
A plasmid-encoded inactive toxin-antitoxin system MtvT/MtvA regulates plasmid conjugative transfer and bacterial virulence in Pseudomonas aeruginosa.
Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- A haloarchaeal VapBC toxin-antitoxin system: regulatory mechanism and role in establishing population heterogeneity to facilitate survival of subpopulations under stress conditions.Applied and environmental microbiology · 2026Article
- Molecular characterization of two conjugative resistance plasmids from a clinical multidrug-resistant ST15 Klebsiella pneumoniae.BMC genomics · 2026Article
- Genomic characterization of the multidrug-resistant IncP-2 plasmid pPAMS in a clinical isolate Pseudomonas aeruginosa.BMC microbiology · 2026Article
- A Review of the Chemical Properties, Mechanisms of Action, and Structure-Activity Relationships of Jellyfish Toxins.Current issues in molecular biology · 2026Review
- The LuxS/AI-2 quorum sensing system regulates osmotic adaptation, motility, and type VI secretion system inFrontiers in microbiology · 2026Article
- Phage-encoded protein PavP modulates Pseudomonas aeruginosa virulence by dual inhibition of growth and pathogenic traits.Biology direct · 2025Article
- Evolution of Resistant Mutants inMicroorganisms · 2025Article
- Prokaryotic homeostasis - a solution to thrive and survive.Frontiers in molecular biosciences · 2025Review
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Authors and funding
13 authors.
Funding
Abstract
Plasmid-encoded toxin-antitoxin (TA) systems are known for their role in plasmid maintenance via post-segregational killing. Here, we identified an inactive type II TA system, MtvT/MtvA (MtvTA), encoded on the conjugative plasmid pPAD8 from the clinical Pseudomonas aeruginosa strain PAD8. Despite its annotation as a toxin, MtvT exhibited no detectable toxicity in our assays. Interestingly, the deletion of the MtvTA significantly increased the transfer efficiency of pPAD8 from PAD8 to P. aeruginosa strain PAO1. Functional assays revealed that the MtvTA complex negatively regulates plasmid transfer by binding to the promoters of dot/icm system genes. In addition, pPAD8ΔmtvTA attenuated the pathogenicity of the host strain compared to pPAD8, highlighting a regulatory role for MtvTA in virulence. Mechanistically, the MtvTA complex positively regulates the type III and type VI secretion systems and pyocyanin biosynthesis by directly binding to the promoters of exsA and rsmY/rsmZ and indirectly influencing lasI expression, respectively. These findings provide new insights into the regulatory roles of an inactive plasmid-encoded TA system, expanding our understanding of the interplay between plasmids and their bacterial hosts.
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