Evidence map›Paper›PMID 39950328›Full record

ArticleInternational journal of oncology2025

Curcumin inhibits the activity of ubiquitin ligase Smurf2 to promote NLRP3‑dependent pyroptosis in non‑small cell lung cancer cells.

Yunzhu Xi, Saili Zeng, Xiaowu Tan, Xiaoyu Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. SMURF2 in Anticancer Therapy: Dual Role in Carcinogenesis and Theranostics.International journal of molecular sciences · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yunzhu XiDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421000, P.R. China.
Saili ZengDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421000, P.R. China.
Xiaowu TanDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421000, P.R. China.
Xiaoyu DengDepartment of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital, University of South China, Hengyang, Hunan 421000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non‑small cell lung cancer (NSCLC) is a malignant tumor of significant clinical relevance. Curcumin has been investigated for its potential anticancer properties, as it has been reported to act through multiple cancer‑related targets and pathways. The present study aimed to explore the effects of curcumin in NSCLC using both

Indexed as

Carcinoma, Non-Small-Cell LungCurcuminLung NeoplasmsNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisUbiquitin-Protein LigasesA549 CellsAnimalsCell Line, TumorCell ProliferationHumansMaleMiceUbiquitinationXenograft Model Antitumor AssaysCurcuminNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanSMURF2 protein, humanUbiquitin-Protein LigasescurcuminNOD‑like receptor pyrin domain‑containing 3non‑small cell lung cancerpyroptosissmad ubiquitination regulatory factor 2

Identifiers

PMID39950328
PMCPMC11844335

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.