Evidence map›Paper›PMID 39950174›Full record

SynthesisFrontiers in psychiatry2025

Premonitory urge in tic disorders - a scoping review.

John B Wohlgemuth, Kelly H Watson, Kayce D Gill, David A Isaacs

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Tourette syndrome.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. From the Mechanisms and Neurobiology to Treatment of Tic Disorders, Including Tourette Syndrome.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026
    Article
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John B WohlgemuthDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York City, NY, United States.
Kelly H WatsonDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.
Kayce D GillAnnette and Irwin Eskind Family Biomedical Library and Learning Center, Vanderbilt University, Nashville, TN, United States.
David A IsaacsDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Funding

Institutional Career Development CoreKL2TR002245 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Julie A. Bastarache · 2017 to 2026
$9.3M
Neurophysiologic Correlates of Sensory Over-Responsivity in Tourette SyndromeK23NS131592 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David A Isaacs · 2023 to 2026
$707k
NCATS NIH HHS KL2 TR002245NINDS NIH HHS K23 NS131592
6 · The paper itself

Abstract

Introduction: Premonitory urges are uncomfortable bodily sensations preceding tics. They are highly prevalent, frequently bothersome, and increasingly recognized as a central phenotypic feature in tic disorder populations. This scoping review aimed to systematically consolidate published knowledge and identify knowledge gaps regarding premonitory urges in primary tic disorders. Methods: Search strategies were deployed in five databases and five topic-relevant journals. Two independent reviewers screened all candidate abstracts against predefined inclusion criteria. One hundred and fifty-five articles were included in the scoping review. The same two reviewers independently extracted and consolidated pertinent data from included articles. Results: Multiple methods for assessing premonitory urge were identified, each with strengths and weaknesses. The subjective quality of premonitory urges varies between individuals, with increased prevalence of a "not just right" urge quality in individuals with comorbid obsessive-compulsive disorder. Awareness of premonitory urge appears to arise several years after tic-onset, yet many individuals perceive their tics as voluntary responses to premonitory urges. Premonitory urges and tics are temporally coupled in real time, but premonitory urge severity and tic severity, as assessed by clinical scales, are not consistently associated. The mechanistic and developmental relationship between premonitory urges and tics remains unclear. Data are limited on premonitory urge response to treatment, but several promising interventions were identified. The insula and supplementary motor area are the neuroanatomical structures most strongly implicated in emergence of the premonitory urge. Discussion: Knowledge of the clinical characteristics, measurement, and neural mechanisms of premonitory urge has advanced considerably in recent years, but important knowledge gaps remain in each of these domains. Addressing these knowledge gaps will be key to developing effective interventions for premonitory urge. Systematic Review Registration: Open Science Framework (OSF) https://doi.org/10.17605/OSF.IO/WT43Z.

Indexed as

premonitory sensationpremonitory urgesensorytictic disorderTourette syndrome

Identifiers

PMID39950174
PMCPMC11821575

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.