ArticleFrontiers in medicine2025
Sepsis in Internal Medicine: blood culture-based subtypes, hospital outcomes, and predictive biomarkers.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Letter to the editor to 'Diagnostic and therapeutic utility of gastric tissue culture in a case of phlegmonous gastritis': reanalysis of the 2015-2025 case series: culture-positive phlegmonous gastritis has lower mortality than culture-negative cases.Clinical journal of gastroenterology · 2026Article
- Bacterial distribution and disease burden analysis in hospital-acquired bloodstream infections according to Diagnosis-Related Groups (DRGs) data.BMC infectious diseases · 2026Article
- Impact of ddPCR panel implementation on optimizing antimicrobial therapy management in critically ill patients with bloodstream infections.Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
Background: Sepsis is a challenging condition increasingly managed in medical wards, however literature and clinical evidence in this hospital setting are lacking. Methods: Using the computational i2b2 framework, we retrospectively analyzed data from patients admitted to internal medicine units of four hospitals in Lombardy (Italy) between January 2012 and December 2023, with a discharge diagnosis of sepsis, septic shock, or septicemia. Results: A total of 4,375 patients were recruited. Median length of stay (LOS) was 14 days, and mean ward-to-intensive care unit (ICU) transfer and in-hospital mortality rates were 11 and 26%, respectively; significant differences were observed over the years, with LOS peaks preceding mortality peaks by 1 year. Blood culture-negative sepses showed shorter stays and higher mortality (acute kidney injury and fast deterioration) compared to culture-positive ones; polymicrobial sepses showed higher ICU transfer rates (acute respiratory distress); while multidrug-resistant (MDR Conclusion: This work provides novel insights into sepsis management in internal medicine units, highlighting the need for validated biomarkers and implemented therapies in this scenario.
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