Evidence map›Paper›PMID 39950118›Full record

ArticleFrontiers in pharmacology2025

Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized controlled trial.

Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chenhui WangDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Mengwei YanDepartment of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China.
Yuru LiInfirmary, Taikang Yanyuan Continuing Care Retirement Community, Beijing, China.
Lei HanInfirmary, Taikang Yanyuan Continuing Care Retirement Community, Beijing, China.
Hongqian WangInfirmary, Taikang Yanyuan Continuing Care Retirement Community, Beijing, China.
Shufeng JiaInfirmary, Taikang Yanyuan Continuing Care Retirement Community, Beijing, China.
Xingchen LiuSchool of Nursing, Harbin Medical University, Harbin, Heilongjiang, China.
Yang LiuDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Fan WuDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.
Baoguo WangDepartment of Anesthesiology, Sanbo Brain Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Knee osteoarthritis (KOA) is a degenerative joint condition, leading to disability and diminished quality of life. Molecular hydrogen has been proven to have antioxidant and anti-inflammatory properties, but few studies have investigated its effects on osteoarthritis. Our study aims to assess the therapeutic potential of hydrogen-oxygen mixture (H Methods: In this randomized controlled trial, eligible elderly KOA patients were randomly assigned to either Group H or Group C. Both groups participated in a 12-week home-based exercise (HBE) program, which included knee-joint exercises and health education. Group H additionally received H Results: A total of 121 subjects were enrolled, with an average age of 81.2 years, and 80.2% were female. The between-group mean difference in the WOMAC total score was -5.2 (95% CI -12.1 to 1.7, P = 0.140) at week 12, with Group H showing an improvement of -22.9 (95% CI -26.3 to -19.6, P < 0.001) and Group C showing an improvement of -19.4 (95% CI -22.7 to -16.0, P < 0.001) compared to baseline, revealing a significant group × time interaction (F (3, 356.034) = 14.425, P < 0.001). No significant differences were observed between both groups at week 12 in CST, TUG, SF-36 scores, EARS scores, or the incidence of adverse events. Conclusion: Although clinical significance was not achieved, H

Indexed as

elderlyexercise therapymolecular hydrogenosteoarthritisWOMAC

Identifiers

PMID39950118
PMCPMC11821916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.