ArticleJournal of pediatrics. Clinical practice2024
Social and Communication Development in Infants with Isolated Agenesis of the Corpus Callosum.
Article in Journal of pediatrics. Clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the development of social behavior, communication, emotion regulation, and repetitive behaviors in infants with congenital malformation of the corpus callosum, specifically those with isolated agenesis of the corpus callosum (ACC), in comparison with infants who are developing typically. Study design: This case-control longitudinal observation study examined parent report of social behavior, social-communication, emotion regulation, and repetitive behavior development in community-ascertained infants (n = 156) and infants with isolated ACC (n = 57) between 12 and 24 months of age. Results: Infants with isolated ACC produced fewer words at 12 ( Conclusions: Existing data suggest heterogeneity in developmental outcomes among individuals with isolated ACC. The current findings fill a gap in knowledge about development in the second year of life. Surveillance of social and communication ability in infants with ACC may be warranted. The role of the corpus callosum in facilitating rapid interhemispheric information processing affects skills beyond the motor system. More work is needed to identify intervention targets for infants and toddlers with ACC.
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