ArticleAmerican journal of cancer research2025
Hinokitiol reduces tumor metastasis by regulating epithelial cell adhesion molecule via protein kinase-B/mammalian target of rapamycin signaling pathway.
Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Reactive oxygen species-dependent regulation of hypoxia-inducible factor 1α/C-X-C motif chemokine receptor 4 signaling promotes ozone-induced cancer metastasis.American journal of cancer research · 2026Article
- Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications.International journal of biological sciences · 2025Article
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8 authors.
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Abstract
Tumor metastasis is the leading cause of death in cancer patients. Epithelial cell adhesion molecule (EpCAM) is abundantly expressed in various malignant tumors and plays a crucial role in cell adhesion, metastasis, proliferation, and differentiation. This study investigated the effects of hinokitiol, a natural tropolone compound known for its antiviral, anti-inflammatory, and antibacterial properties, on tumor growth and metastasis. Specifically, the study focused on the expression of EpCAM in mouse tumor cells treated with hinokitiol. Hinokitiol was administered to mouse melanoma cells (B16F10) and mouse colorectal carcinoma cells (CT26), resulting in a significant decrease in EpCAM expression. Additionally, the protein levels involved in the protein kinase-B/mammalian target of rapamycin (AKT/mTOR) signaling pathway were reduced following hinokitiol treatment. Using wound healing and Transwell assays, the study demonstrated that hinokitiol effectively inhibits cancer cell migration.
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