Evidence map›Paper›PMID 39949834›Full record

ArticleNeural plasticity2025

Overexpression of SFPQ Improves Cognition and Memory in AD Mice.

Jinshan Tie, Hongxiang Wu, Wei Liu, Yuying Li, Lu Li, Suju Zhao, Zhijiao Yuan, Khan Mahmood, Shaochun Chen, Huidong Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural plasticity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jinshan TieSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.ORCID 0000-0002-4776-7132
Hongxiang WuSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Wei LiuSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Yuying LiSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Lu LiSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Suju ZhaoSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Zhijiao YuanSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.
Khan MahmoodSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.ORCID 0009-0005-2853-2054
Shaochun ChenSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.ORCID 0000-0003-4915-5962
Huidong WuSchool of Rehabilitation, Kunming Medical University, Kunming 650500, Yunnan Province, China.ORCID 0000-0001-9463-9240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder with multifaceted pathogenesis, which has been extensively investigated, yet effective treatments remain lacking. Splicing factor proline and glutamine rich (SFPQ) is known to play a crucial role in neurodegenerative diseases, including antioxidant-related functions and regulating gene expression within brain neurons. However, the specific role of SFPQ in AD pathology is not well understood. In this study, an AD mouse model was established through lateral ventricular injection of amyloid-beta

Indexed as

Alzheimer DiseaseCognitionMemoryPTB-Associated Splicing FactorAmyloid beta-PeptidesAnimalsDisease Models, AnimalHippocampusMaleMiceMice, Inbred C57BLMice, TransgenicPeptide FragmentsAmyloid beta-Peptidesamyloid beta-protein (1-42)Peptide FragmentsPTB-Associated Splicing Factor

Identifiers

PMID39949834
PMCPMC11824863

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.