Evidence map›Paper›PMID 39949809›Full record

ArticleChinese herbal medicines2025

Metabolome and transcriptome association study reveals biosynthesis of specialized benzylisoquinoline alkaloids in

Tingxia Liu, Wanran Zhang, Sijia Wang, Ya Tian, Yifan Wang, Ranran Gao, Shilin Chen, Wei Sun, Wei Ma, Zhichao Xu

Abstract read
In one paragraph

Article in Chinese herbal medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. An Updated and Comprehensive Review ofMolecules (Basel, Switzerland) · 2026
    Review
  3. A review ofChinese herbal medicines · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingxia LiuCollege of Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Wanran ZhangCollege of Life Sciences, Northeast Forestry University, Harbin 150040, China.
Sijia WangCollege of Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Ya TianCollege of Life Sciences, Northeast Forestry University, Harbin 150040, China.
Yifan WangCollege of Life Sciences, Northeast Forestry University, Harbin 150040, China.
Ranran GaoKey Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Shilin ChenKey Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei SunKey Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Wei MaCollege of Pharmaceutical Sciences, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Zhichao XuCollege of Life Sciences, Northeast Forestry University, Harbin 150040, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Benzylisoquinoline alkaloids (BIAs) have pharmacological functions and clinical use. BIAs are mainly distributed in plant species across the order Ranunculales and the genus Methods: The transcriptome and metabolome data from 18 different tissues of Results: The synonymous substitutions per synonymous site for paralogs indicated that at least one whole genome duplication event has occurred. The potential BIA biosynthetic pathway of Conclusion: Our studies provide important insights into the biosynthesis and evolution of BIAs in non-Ranunculales species.

Indexed as

benzylisoquinoline alkaloidsbiosynthesisevolutionnorcoclaurine synthasePhellodendron amurense Rupr

Identifiers

PMID39949809
PMCPMC11814251

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.