ArticleFrontiers in neurology2025
Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Article
- Utility of Functional Near-infrared Spectroscopy (fNIRS) in Major Depressive Disorder: A Systematic Review.Indian journal of psychological medicine · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: It has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. Furthermore, clarifying the mechanisms underlying variations in executive function impairments across multiple psychiatric disorders will enhance our comprehension of brain activity alternations among these disorders. Therefore, this study combined the VFT and the functional near-infrared spectroscopy (fNIRS) to investigate the neural mechanisms underlying the impairment of executive function across psychiatric disorders including anxiety disorder (AD), sleep disorder (SD) and major depressive disorder (MDD). Methods: Two hundred and eight participants were enrolled including 52 AD, 52 SD, 52 MDD and 52 healthy controls (HCs). All participants completed the VFT while being monitored using fNIRS to measure changes in brain oxygenated hemoglobin (Oxy-Hb). Results: Our results demonstrated that MDD, AD and SD exhibited decreased overall connectivity strength, as well as reduced connected networks involving the frontal and temporal regions during the VFT comparing to HC. Furthermore, the MDD group showed a reduction in connected networks, specifically in the left superior temporal gyrus and precentral gyrus, compared to the AD group. Conclusion: Our study offers neural evidence that the VFT combined with fNIRS could effectively detect executive function impairment in different psychiatric disorders.
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