Evidence map›Paper›PMID 39949484›Full record

ArticleOrgans-on-a-chip2023

Simple design for membrane-free microphysiological systems to model the blood-tissue barriers.

Ashlyn T Young, Halston Deal, Gabrielle Rusch, Vladimir A Pozdin, Ashley C Brown, Michael Daniele

Abstract read
In one paragraph

Article in Organs-on-a-chip, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. HumanBioactive materials · 2026
    Article
  2. Article
  3. 3DFrontiers in pharmacology · 2025
    Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Ashlyn T YoungJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695, USA.
Halston DealJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695, USA.
Gabrielle RuschJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695, USA.
Vladimir A PozdinDepartment of Electrical & Computer Engineering, Florida International University, Miami, FL, USA.
Ashley C BrownJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695, USA.
Michael DanieleJoint Department of Biomedical Engineering, North Carolina State University and University of North Carolina, Chapel Hill, 911 Oval Dr., Raleigh NC, 27695, USA.

Funding

Pre-doctoral Training Program in Integrative Vascular BiologyT32HL069768 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Christopher P. Mack · 2002 to 2026
$9.7M
Synthesis and Chemical Biology of Bioactive Natural ProductsR35GM139583 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIERCE, JOSHUA G. · 2021 to 2025
$2.5M
Training Grant in Comparative Molecular MedicineT32GM133393 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Matthew B Fisher, Caroline Laplante · 2021 to 2026
$1.7M
NC State Chemistry of Life Training Program (CLTP)T32GM141887 · NIGMS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI PIERCE, JOSHUA G. · 2021 to 2025
$1.3M
NHLBI NIH HHS T32 HL069768NIGMS NIH HHS R35 GM139583NIGMS NIH HHS T32 GM133393NIGMS NIH HHS T32 GM141887
6 · The paper itself

Abstract

Microphysiological systems (MPS) incorporate physiologically relevant microanatomy, mechanics, and cells to mimic tissue function. Reproducible and standardized

Indexed as

Blood-brain barrierEndothelial cellsMicrofluidicsMicrophysiological systemTissue barrier

Identifiers

PMID39949484
PMCPMC11823427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.