ArticleCureus2025
Neutrophil-to-Lymphocyte Ratio as a Biomarker for Motor Subtypes in Idiopathic Parkinson's Disease.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Multidimensional Characterization of Parkinson's Disease Subtypes Through Motor Neuron Excitability and Peripheral Immune Dynamics: Insights from F-Wave Modulation Metrics.Diagnostics (Basel, Switzerland) · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundParkinson's disease (PD) is one of the most common neurodegenerative disorders, primarily affecting movement and motor function. Described by the symptoms, including tremors, rigidity, bradykinesia, and postural instability, PD presents clinical heterogeneity in patients, which complicates diagnostic and therapeutic interventions.
objectiveThe study aimed to find the neutrophil-to-lymphocyte ratio (NLR) as a biomarker for motor subtypes in idiopathic PD. MATERIALS AND
methodsThis prospective observational study was conducted at Chiniot General Hospital Karachi, Pakistan, from January 2023 to January 2024. Data were collected from 55 patients suffering from idiopathic PD. Demographic and clinical data were collected for each patient, including age, sex, disease duration, and medications used for PD management.
resultsThere was no significant difference between the tremor-dominant (TD) and postural instability and gait difficulty (PIGD) subtypes in terms of age (p = 0.45), sex distribution (p = 0.62), or disease duration (p = 0.68). However, the Hoehn and Yahr scale, which measures disease severity, was significantly higher in the PIGD subtype (2.9 ± 0.6) compared to the TD subtype (2.4 ± 0.5) with a p-value of 0.03, indicating greater disease severity in the PIGD group. The results indicate that the NLR was significantly higher in the PIGD subtype (3.17 ± 0.89) than in the TD subtype (2.41 ± 0.72), with a p-value of 0.01. This suggests a stronger inflammatory response in the PIGD subtype, which could be linked to greater disease severity in these patients.
conclusionThe NLR can be a potential biomarker for distinguishing motor subtypes in idiopathic PD.
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