Evidence map›Paper›PMID 39949344›Full record

ReviewFrontiers in public health2024

Physical parameters and biological factors affect the abscopal effect of combining radiotherapy with immunotherapy: an update on preclinical works.

Wangcai Ren, Jialing Wen, Gang Guo, Wenchao Gu, Shenke Zhang, Chang Liu, Kensuke Osada, Takashi Shimokawa, Qiaojuan Wang, Yue Wang and 4 more

Erratum issuedAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Wangcai Ren *Department of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.
Jialing Wen *National Innovation Center of Radiation Application, Beijing, China.
Gang GuoDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.
Wenchao GuDepartment of Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Shenke ZhangMarshall Laboratory of Biomedical Engineering, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen University, Shenzhen, China.
Chang LiuDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Kensuke OsadaDepartment of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Takashi ShimokawaDepartment of Accelerator and Medical Physics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.
Qiaojuan WangDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.
Yue WangDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.
Xuanzhang TuDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.
Chen LiChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China.
Li SuiNational Innovation Center of Radiation Application, Beijing, China.
Liqiu MaDepartment of Nuclear Physics, China Institute of Atomic Energy, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the process of radiotherapy for cancer patients, there is an extremely low probability phenomenon that the distal tumor/metastasis away from the irradiation field undergoes regression after localized radiation therapy, which is called the abscopal effect. Enhancing the incidence of this phenomenon possesses profound significance for the investigation of metastatic cancer treatment. Currently, the underlying mechanisms of the abscopal effect remain unclear. Radiation-induced immunogenic cell death is considered one of the potential mechanisms for the abscopal effect. From this perspective, we explored how physical parameters and biological factors influence this process. Differences between patients with respect to physical factors and intrinsic biological factors that activate the immune response (acquired factors) may affect the induction of the abscopal effect.

Indexed as

ImmunotherapyNeoplasmsRadiotherapyCombined Modality TherapyHumansabscopal effectbiological factorsimmunogenic cell deathphysical parametersradiotherapy

Identifiers

PMID39949344
PMCPMC11822297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.