Evidence map›Paper›PMID 39949333›Full record

ArticleMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents2024

A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy.

Srinivas Rao Mandalapu, Shanshan Hou, Steffen Jockusch, Zhiying Shan, Lanrong Bi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Srinivas Rao MandalapuDepartment of Chemistry, Michigan Technological University, Houghton, MI 49930, USA.
Shanshan HouDepartment of Chemistry, Michigan Technological University, Houghton, MI 49930, USA.
Steffen JockuschCenter of Photochemical Sciences, Bowling Green State University, Ohio 43403, USA.
Zhiying ShanDepartment of Kinesiology and Integrative Physiology, Michigan Technological University, Houghton, MI 49930, USA.
Lanrong BiDepartment of Chemistry, Michigan Technological University, Houghton, MI 49930, USA.ORCID 0000-0001-6624-8314

Funding

Contribution of Orexin System to HypertensionR01HL163159 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI SHAN, ZHIYING · 2022 to 2025
$1.7M
NHLBI NIH HHS R01 HL163159
6 · The paper itself

Abstract

Free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS) cause cellular damage and contribute to thromboembolic diseases by promoting platelet activation and aggregation. Compounds that scavenge free radicals can reduce oxidative stress, decreasing platelet aggregation and thrombus formation. Despite their beneficial biological activities, indoles have clinical limitations due to poor bioavailability, solubility, rapid metabolism, and limited membrane permeability. We designed a new class of indole derivatives (

Indexed as

Anti-platelet aggregation activityFree radical scavenging activityIndole derivativesPermeability

Identifiers

PMID39949333
PMCPMC11822782

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.