Evidence map›Paper›PMID 39949307›Full record

ArticleAnalytical chemistry2025

Chemical Analysis of Deep-Lung Fluid Derived from Exhaled Breath Particles.

Tayeb Kakeshpour, John M Louis, Peter J Walter, Ad Bax

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Organic components modulate the morphology of respirable aerovirology-relevant aerosols.Aerosol science and technology : the journal of the American Association for Aerosol Research · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tayeb KakeshpourLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.
John M LouisLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-0052-1899
Peter J WalterNational Institute of Diabetes and Digestive and Kidney Diseases, Clinical Mass Spectrometry Core, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ad BaxLaboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID 0000-0002-9809-5700

Funding

Observation and quantification of respiratory droplets by laser light scatteringZIADK075154 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI BAX, ADRIAAN · 2020 to 2025
$2.5M
Intramural NIH HHS ZIA DK075154
6 · The paper itself

Abstract

Breath particles generated deep within the lung provide noninvasive access to sampling nonvolatiles in peripheral airway lining fluid. However, background contamination, their variable production among subjects, together with a huge unknown dilution when using the common breath condensate method for collection has limited their use for quantitative biomarker analysis. Instead, we first capture and dry the particles in a flexible chamber followed by accurate optical particle characterization during their collection for chemical analysis. By decoupling breathing and aerosol sampling airflows, this sequential approach not only accommodates all types of breathing routines but also enables the use of a variety of aerosol samplers for downstream biomarker analysis. Using

Indexed as

Bronchoalveolar Lavage FluidExhalationLungAerosolsBiomarkersBreath TestsHumansMagnetic Resonance SpectroscopyParticle SizeAerosolsBiomarkers

Identifiers

PMID39949307
PMCPMC11859745

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.