Evidence map›Paper›PMID 39949251›Full record

ArticleAnales del sistema sanitario de Navarra2025

Association between pre-existing cardiovascular risk factors and post-acute sequelae of COVID-19 in older adults.

Guilherme José Silva Ribeiro, André de Araújo Pinto, Gabriela Corrêa Souza, Emilio Hideyuki Moriguchi

Abstract read
In one paragraph

Article in Anales del sistema sanitario de Navarra, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. [Anales del Sistema Sanitario de Navarra in 2025: Progress continues].Anales del sistema sanitario de Navarra · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Risk factors for post-COVID-19 condition: A case-control study in municipalities of Paraíba and Rio de Janeiro, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guilherme José Silva RibeiroFederal University of Viçosa. guilherme.j.ribeiro@ufv.br.
André de Araújo PintoState University of Roraima. Health Sciences Center. Boa Vista. Brazil. andre.pinto@uerr.edu.br.
Gabriela Corrêa SouzaFederal University of Rio Grande do Sul. School of Medicine. Department of Nutrition and Graduate Program in Food. gcsouza@hcpa.edu.br.
Emilio Hideyuki MoriguchiFederal University of Rio Grande do Sul. School of Medicine. Graduate Program in Cardiology and Cardiovascular Sciences. Porto Alegre. Brazil . emoriguchi@hcpa.edu.b.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe long-term health impacts of COVID-19, including post-acute sequelae of SARS-CoV-2, remain insufficiently explored, especially concerning pre-existing cardiovascular risk factors in older adults. This study examines the association between these risk factors and post-acute sequelae of SARS-CoV-2 in this population.

methodsA retrospective study of Brazilian adults aged = 60 years assessed the persistence of post-acute sequelae of SARS-CoV-2 three months after infection in 2020. Cardiovascular risk factors (obesity, smoking, high blood pressure, diabetes mellitus, hypercholesterolemia, and chronic kidney disease) were analyzed in relation to sequelae and adjusting for sociodemographic variables. Data were obtained from the Department of Epidemiological Surveillance in Roraima, Brazil.

resultsOf the 1,322 participants (55% female; mean age 70.4 years, SD = 7.87), 61.7% (95% CI: 59.1-63.9) reported at least one post-acute sequelae of SARS-CoV-2 at the three-month follow-up. The likelihood of post-acute sequelae of SARS-CoV-2 was significantly higher in participants with diabetes mellitus (OR = 4.39; 95% CI: 3.42-5.66), tobacco use (OR = 3.93; 95% CI: 2.47-6.23), hypertension (OR = 3.62; 95% CI: 2.73-4.78), or hypercholesterolemia (OR = 3.58; 95% CI: 2.80-4.59). Chronic kidney disease (OR = 2.28; 95% CI: 1.59-3.25) and obesity (OR = 1.83; 95% CI: 1.28-2.61) were less strongly associated.

conclusionsPre-existing cardiovascular risk factors are linked to a higher likelihood of long-term COVID-19 sequelae in adults aged = 60 years old. Preventing and managing these factors are crucial for reducing the long-term effects of COVID-19, particularly during a pandemic.

Indexed as

Cardiovascular DiseasesCOVID-19Heart Disease Risk FactorsAgedBrazilDiabetes MellitusFemaleHumansHypercholesterolemiaMaleMiddle AgedPost-Acute COVID-19 SyndromeRetrospective StudiesRisk FactorsSmoking

Identifiers

PMID39949251
PMCPMC11925477

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.