Evidence map›Paper›PMID 39948738›Full record

ArticleAmerican journal of physical medicine & rehabilitation2025

Network Medicine as a Tool to Enhance Regenerative Rehabilitation Practice.

Hirotaka Iijima, Fabrisia Ambrosio

Abstract read
In one paragraph

Article in American journal of physical medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Sexual Dimorphism in Clinical Manifestations of Knee Osteoarthritis.Medicine and science in sports and exercise · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hirotaka IijimaFrom the Discovery Center for Musculoskeletal Recovery, Schoen Adams Research Institute at Spaulding, Charlestown, Massachusetts (HI, FA); Department of Physical Medicine & Rehabilitation, Harvard Medical School, Boston, Massachusetts (HI, FA); and Department of Physical Medicine & Rehabilitation, Spaulding Rehabilitation Hospital, Charlestown, Massachusetts (HI, FA).ORCID 0000-0001-5504-1502
Fabrisia AmbrosioORCID 0000-0002-5497-5968

Funding

Technology Development P2CHD086843 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSIO, FABRISIA · 2015 to 2024
$10.5M
Sex Dimorphism in Age-Related Knee OsteoarthritisR01AG089455 · NIA · SPAULDING REHABILITATION HOSPITAL · PI Fabrisia Ambrosio, Hirotaka Iijima · 2024 to 2026
$1.7M
NIA NIH HHS R01 AG089455NICHD NIH HHS P2C HD086843
6 · The paper itself

Abstract

objectiveThe aim of the study was to demonstrate the utility of network medicine for enhancing regenerative rehabilitation approaches.

designWe employed a scientometric approach to illustrate the scientific evolution of regenerative rehabilitation and network medicine over the past 20 yrs. We then present two exemplars of a novel application of network medicine, first to optimize the development of a multimodal rehabilitation program for osteoarthritis and, second, to demonstrate the potential utility of a regenerative rehabilitation protocol for neurological applications.

resultsThe scientometric analysis revealed thematic clusters guiding the fields of regenerative rehabilitation, while also revealing a notable gap in the integration of advanced computational biology tools, such as network medicine. To address this gap, we applied a network medicine paradigm as a proof-of-principle in rehabilitation, demonstrating its ability to predict previously known combinational benefits of a multimodal rehabilitation protocol for osteoarthritis and potential of a regenerative rehabilitation protocol to enhance outcomes after stroke.

conclusionsThe trajectory of progress in regenerative rehabilitation has been defined by embracing new technologies and approaches. We propose that network medicine is a new frontier for the field. Toward the design of efficient and optimized clinical protocols, we anticipate that the network medicine paradigm may have broad applications in the field of rehabilitation, even beyond the examples presented here.

Indexed as

OsteoarthritisRegenerative MedicineStroke RehabilitationHumans

Identifiers

PMID39948738
PMCPMC13104631

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.