Evidence map›Paper›PMID 39948704›Full record

ReviewCancer reports (Hoboken, N.J.)2025

Synchronous Hepatocellular and Intrahepatic Cholangiocellular Carcinoma With Predominant Ductal Plate Malformation Pattern. A Case Report and Review of the Literature.

Rita Szodorai, Emőke Fülöp, Andrei Fülöp, Radu Mircea Neagoe, Simona Gurzu

Abstract readCase ReportsReview
In one paragraph

Review in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rita SzodoraiDepartment of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu-Mureș, Romania.
Emőke FülöpDepartment of Pathology, Clinical County Emergency Hospital, Târgu-Mureș, Romania.
Andrei FülöpDepartment of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu-Mureș, Romania.
Radu Mircea NeagoeDepartment of Surgery, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu-Mureș, Romania.
Simona GurzuDepartment of Pathology, George Emil Palade University of Medicine, Pharmacy, Science and Technology, Târgu-Mureș, Romania.ORCID 0000-0003-3968-5118

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSynchronous occurrence of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) is extremely rare. CASE: A 67-year-old male was admitted to the hospital with hemoperitoneum caused by a liver mass rupture and elevated serum liver enzymes. Abdominal magnetic resonance imaging revealed a solid mass, with 38 mm in maximum diameter, located in the fifth/sixth segments of the liver, suggesting an HCC. Emergency surgery was performed and a second liver mass in the fourth segment was identified intraoperatively, with 20 mm in maximum diameter. Hepatic resection of the affected segments was performed with free resection margins. Histopathological examination revealed the synchronous occurrence of HCC and ICC with a predominant ductal plate malformation pattern. The patient is still alive at 41 months after its first surgery.

conclusionsIn patients with HCC, a proper intraoperative assessment is indicated, in addition to imaging investigations, to detect synchronous lesions that can change the therapeutic approach. This is the first case ever reported in the literature in which synchronous HCC and ICC with a predominant ductal plate malformation pattern were incidentally diagnosed in a patient with hemoperitoneum.

Indexed as

Bile Duct NeoplasmsCarcinoma, HepatocellularCholangiocarcinomaLiver NeoplasmsNeoplasms, Multiple PrimaryAgedBile Ducts, IntrahepaticHepatectomyHumansMagnetic Resonance ImagingMalecase reportductal plate malformationhepatocellular carcinomasynchronous tumors

Identifiers

PMID39948704
PMCPMC11825378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.