ArticleJournal of anesthesia, analgesia and critical care2025
Intraoperative hemodynamic management in abdominal aortic surgery guided by the Hypotension Prediction Index: the Hemas multicentric observational study.
Article in Journal of anesthesia, analgesia and critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
INTRAOPERATIVE HEMODYNAMIC MANAGEMENT IN ABDOMINAL AORTIC SURGERY GUIDED BY HYPOTENSION PREDICTION INDEX (HPI) - HEMAS Trial
The Hypotension Prediction Index Software Compared With Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery: A Prospective Randomized Controlled Trial
Who cites it
1 citing paper in PubMed.
- Hypotension Prediction Index Software Compared with Standard Advanced Haemodynamic Monitoring in Patients Undergoing Major Aortic Surgery: A Retrospective Study.Journal of clinical medicine · 2025Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative hypotension (IOH) during non-cardiac surgery is closely associated with postoperative complications. Hypotensive events are more likely during major open vascular surgery. We prospectively investigated whether our institutional algorithm of cardiocirculatory management, which included the Hypotension Prediction Index (HPI), a predictive model of hypotension of the Hemosphere™ platform (Edwards Lifescience, Irwin, CA, USA), was able to reduce the incidence and severity of intraoperative hypotension during open abdominal aortic aneurysm repair.
methodsA multi-center observational study was conducted at IRCCS-Humanitas Research Hospital (Milan) and AO Mauriziano Umberto I Hospital (Turin) between July 2022 and September 2023, enrolling patients undergoing elective open abdominal aortic aneurysm repair. A hemodynamic protocol based on the Acumen-HPI Hemosphere™ platform was employed, integrating advanced parameters (e.g., HPI, Ea-dyn, dP/dt) and tailored interventions to minimize intraoperative hypotension. The primary endpoint was cumulative intraoperative hypotension time < 10% of surgical time, with secondary endpoints including incidence of hypotensive events, time-weighted averages of MAP < 65 mmHg (TWA65) and < 50 mmHg (TWA50), and postoperative complications.
resultsWe enrolled 53 patients submitted to open abdominal aortic repair. The primary endpoint (time in hypotension < 10%) was successfully reached: 5 [1-10] %. The targeted time-weighted average (< 0.40 mmHg) both for MAP < 65 mmHg (TWA65) and MAP < 50 mmHg (severe hypotension; TWA50) were reached: TWA65 = 0.26 [0.04-0.65] mmHg and TWA50 = 0.00 [0.00-0.01].
conclusionsOur hemodynamic management algorithm based on the HPI and other parameters of the Hemosphere™ platform was able to limit the incidence and severity of intraoperative hypotension during open abdominal aortic repair.
trial registrationNCT05478564.
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