Evidence map›Paper›PMID 39948641›Full record

ArticleWorld journal of emergency surgery : WJES2025

Indocyanine green fluorescence-guided surgery in the emergency setting: the WSES international consensus position paper.

Belinda De Simone, Fikri M Abu-Zidan, Luigi Boni, Ana Maria Gonzalez Castillo, Elisa Cassinotti, Francesco Corradi, Francesco Di Maggio, Hajra Ashraf, Gian Luca Baiocchi, Antonio Tarasconi and 32 more

Abstract readConsensus Statement
In one paragraph

Article in World journal of emergency surgery : WJES, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors.

Belinda De SimoneDepartment of Emergency and General Minimally Invasive Surgery, Infermi Hospital, AUSL Romagna, Rimini, Italy. desimone.belinda@gmail.com.
Fikri M Abu-ZidanDepartment of Surgery, College of Medicine and Health Sciences, United Arab Emirates University, Al‑Ain, UAE.
Luigi BoniDepartment of General and Minimally Invasive Surgery, Fondazione IRCCS - Ca' Granda - Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Ana Maria Gonzalez CastilloEmergency Surgery Unit, Department of General Surgery, Pompeu Fabra University, Hospital del Mar, Barcelona, Spain.
Elisa CassinottiDepartment of General and Minimally Invasive Surgery, Fondazione IRCCS - Ca' Granda - Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Francesco CorradiDepartment of Surgical, Medical andMolecularPathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Francesco Di MaggioUpper Gastro-Intestinal Surgery Unit, Department of General Surgery, Croydon University Hospital, London, UK.
Hajra AshrafUpper Gastro-Intestinal Surgery Unit, Department of General Surgery, Croydon University Hospital, London, UK.
Gian Luca BaiocchiUnit of General Surgery, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Antonio TarasconiUOC General Surgery, ASST Cremona, Cremona, Italy.
Martina BonafedeUOC General Surgery, ASST Cremona, Cremona, Italy.
Hung TruongAcute Care and Minimally Invasive Surgery, Scripps Memorial Hospital - La Jolla, Green, and Encinitas, La Jolla, USA.
Nicola De'AngelisUnit of Robotic and Minimally Invasive Digestive Surgery, Ferrara University Hospital, Ferrara, Italy.
Michele DianaDepartment of Surgery, University Hospital of Geneva, 1205, Geneva, Switzerland.
Raul CoimbraRiverside University Health System Medical Center, Riverside, CA, USA.
Zsolt J BaloghDepartment of Traumatology, John Hunter Hospital and University of Newcastle, Newcastle, NSW, Australia.
Elie ChouillardGeneral Surgery Department, American Hospital of Paris, Paris, France.
Federico CoccoliniDepartment of General Surgery, University Hospital of Pisa, Pisa, Italy.
Micheal Denis KellyMedAlliance, Albury, NSW, Australia.
Salomone Di SaverioGeneral Surgery Unit, Madonna del Soccorso Hospital, AST Ascoli Piceno, San Benedetto del Tronto, Italy.
Giovanna Di MeoDepartment of Precision and Regenerative Medicine and Ionian Area, Unit of Academic General Surgery, University of Bari "A. Moro", Bari, Italy.
Arda IsikIstanbul Medeniyet University, Istanbul, Turkey.
Ari LeppäniemiDivision of Emergency Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Andrey LitvinDepartment of Surgical Diseases No. 3, Gomel State Medical University, University Clinic, Gomel, Belarus.
Ernest E MooreErnest E Moore Shock Trauma Center at Denver Health, University of Colorado, Denver, CO, USA.
Alessandro PasculliDepartment of Precision and Regenerative Medicine and Ionian Area, Unit of Academic General Surgery, University of Bari "A. Moro", Bari, Italy.
Massimo SartelliDepartment of General Surgery, Macerata Hospital, Macerata, Italy.
Mauro PoddaDepartment of Surgical Science, Unit of Emergency Surgery, University of Cagliari, Cagliari, Italy.
Mario TestiniDepartment of Precision and Regenerative Medicine and Ionian Area, Unit of Academic General Surgery, University of Bari "A. Moro", Bari, Italy.
Imtiaz WaniDepartment of Surgery, Government Gousia Hospital, DHS, Srinagar, India.
Boris SakakushevGeneral Surgery Department, Medical University, University Hospital St George, Plovdiv, Bulgaria.
Vishal G ShelatDepartment of General Surgery, Tan Tock Seng Hospital, Novena, Singapore.
Dieter WeberDepartment of General Surgery, Royal Perth Hospital & The University of Western Australia, Perth, Australia.
Joseph M GalanteUC Davis Health, Hospital Clinical Care Services, University of California, Davis, USA.
Luca AnsaloniDepartment of General Surgery, University of Pavia, Pavia, Italy.
Vanni AgnolettiLevel 1 Trauma Center, Bufalini Hospital, AUSL Romagna, Cesena, Italy.
Jean-Marc RegimbeauService de Chirurgie Digestive du CHU d'Amiens, CHU Sud, Centre Hospitalier Universitaire Amiens-Picardie Site Sud, 80054, Amiens, France.
Gianluca GarulliDepartment of Emergency and General Minimally Invasive Surgery, Infermi Hospital, AUSL Romagna, Rimini, Italy.
Andrew L KirkpatrickDepartments of Surgery and Critical Care Medicine, University of Calgary, Foothills Medical Centre, Calgary, AB, Canada.
Walter L BifflDivision of Trauma/Acute Care Surgery, Scripps Clinic Medical Group, La Jolla, CA, USA.
ICG-Fluorescence Guided Emergency Surgery Consensus Participants
Fausto CatenaDepartment of General and Emergency Surgery, Bufalini Hospital-Level 1 Trauma Center, AUSL Romagna, Cesena, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDecision-making in emergency settings is inherently complex, requiring surgeons to rapidly evaluate various clinical, diagnostic, and environmental factors. The primary objective is to assess a patient's risk for adverse outcomes while balancing diagnoses, management strategies, and available resources. Recently, indocyanine green (ICG) fluorescence imaging has emerged as a valuable tool to enhance surgical vision, demonstrating proven benefits in elective surgeries.

aimThis consensus paper provides evidence-based and expert opinion-based recommendations for the standardized use of ICG fluorescence imaging in emergency settings.

methodsUsing the PICO framework, the consensus coordinator identified key research areas, topics, and questions regarding the implementation of ICG fluorescence-guided surgery in emergencies. A systematic literature review was conducted, and evidence was evaluated using the GRADE criteria. A panel of expert surgeons reviewed and refined statements and recommendations through a Delphi consensus process, culminating in final approval.

resultsICG fluorescence imaging, including angiography and cholangiography, improves intraoperative decision-making in emergency surgeries, potentially reducing procedure duration, complications, and hospital stays. Optimal use requires careful consideration of dosage and timing due to limited tissue penetration (5-10 mm) and variable performance in patients with significant inflammation, scarring, or obesity. ICG is contraindicated in patients with known allergies to iodine or iodine-based contrast agents. Successful implementation depends on appropriate training, availability of equipment, and careful patient selection.

conclusionsAdvanced technologies and intraoperative navigation techniques, such as ICG fluorescence-guided surgery, should be prioritized in emergency surgery to improve outcomes. This technology exemplifies precision surgery by enhancing minimally invasive approaches and providing superior real-time evaluation of bowel viability and biliary structures-areas traditionally reliant on the surgeon's visual assessment. Its adoption in emergency settings requires proper training, equipment availability, and standardized protocols. Further research is needed to evaluate cost-effectiveness and expand its applications in urgent surgical procedures.

Indexed as

Indocyanine GreenOptical ImagingSurgery, Computer-AssistedConsensusDelphi TechniqueHumansIndocyanine GreenAngiographyArtificial intelligenceCholangiographyEmergencyFluorescenceIndocyanine greenModern surgeryPracticePrecisionSurgeryTechnologyWorld society of emergency surgery

Identifiers

PMID39948641
PMCPMC11823064

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.