Evidence map›Paper›PMID 39948424›Full record

ArticleScientific reports2025

Intratumoral administration of mRNA COVID-19 vaccine delays melanoma growth in mice.

Dylan T Boehm, Kaitlyn M Landreth, Emel Sen Kilic, Katherine S Lee, Bishal Misra, Sharan Bobbala, F Heath Damron, Tracy W Liu

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dylan T BoehmDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.
Kaitlyn M LandrethDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.
Emel Sen KilicDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.
Katherine S LeeDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.
Bishal MisraDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.
Sharan BobbalaDepartment of Pharmaceutical Sciences, West Virginia University, Morgantown, WV, 26506, USA.
F Heath DamronDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA.
Tracy W LiuDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University, 64 Medical Center Drive, Morgantown, WV, 26506, USA. tracy.liu@hsc.wvu.edu.ORCID 0000-0003-0671-8390

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Stephenie Kay Kennedy-Rea · 2012 to 2026
$81.0M
WVU Flow Cytometry and Single Cell Core Facility (FCSCCF)P20GM121322 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Karen H Martin · 2018 to 2026
$22.4M
Special Becton Dickinson Fortessa Flow CytometerS10OD016165 · OD · WEST VIRGINIA UNIVERSITY · PI CUFF, CHRISTOPHER F · 2013 to 2013
$384k
Cytek 3-laser AuroraS10OD028605 · OD · WEST VIRGINIA UNIVERSITY · PI BRUNDAGE, KATHLEEN M · 2021 to 2021
$259k
NIGMS NIH HHS 5P20GM121322NIGMS NIH HHS P20 GM121322NIGMS NIH HHS U54 GM104942NIH HHS S10 OD016165NIH HHS S10 OD028605
6 · The paper itself

Abstract

Immunotherapies are effective for cancer treatment but are limited in 'cold' tumor microenvironments due to a lack of infiltrating CD8

Indexed as

COVID-19 VaccinesMelanomamRNA VaccinesTumor MicroenvironmentAdjuvants, VaccineAnimalsCD8-Positive T-LymphocytesCell Line, TumorDisease Models, AnimalFemaleImmune Checkpoint InhibitorsMiceMice, Inbred C57BLSurvival AnalysisAdjuvants, VaccineCOVID-19 VaccinesImmune Checkpoint InhibitorsmRNA VaccinesCOVID-19 vaccineImmunotherapyMelanomamRNA vaccineT cell infiltration

Identifiers

PMID39948424
PMCPMC11825918

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.