Evidence map›Paper›PMID 39948386›Full record

ArticlePediatric research2025

Bartter syndrome as natural experiment if furosemide (re)opens the ductus arteriosus.

Tim Hundscheid, Michiel F Schreuder, Willem P de Boode

Abstract readLetter
PubMed Publisher
In one paragraph

Article in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tim HundscheidRadboudumc Amalia Children's Hospital, Department of Pediatrics, Division of Neonatology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands. tim.hundscheid@radboudumc.nl.ORCID http://orcid.org/0000-0002-5143-2845
Michiel F SchreuderRadboudumc Amalia Children's Hospital, Department of Pediatric Nephrology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Willem P de BoodeRadboudumc Amalia Children's Hospital, Department of Pediatrics, Division of Neonatology Internal postal code 804, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impactFurosemide increases renal prostaglandin synthesis and animal studies show reopening of the ductus arteriosus in rats exposed to furosemide. Nevertheless, large cohort studies in preterm infants do not support this hypothesis. Bartter syndrome, a rare genetic renal disorder with excessive fluid and salt-loss, is similar to continuous furosemide exposure. We hypothesize that Bartter syndrome could be considered as a natural experiment. Although most infants with Bartter syndrome are born prematurely, there are no cases found in literature with a patent ductus arteriosus which suggest that the contribution of furosemide to (re)opening of the ductus arteriosus in humans might be negligible.

Indexed as

Bartter SyndromeDiureticsDuctus ArteriosusDuctus Arteriosus, PatentFurosemideAnimalsHumansInfant, NewbornInfant, PrematureRatsDiureticsFurosemide

Identifiers

PMID39948386

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.