Trial reportScientific reports2025
Testing the iMplementation Framework fOr behavioral and LIfestyLe interventions in AlZheimer's DiseasE (MOBILIZE) via the ACT randomized controlled trial.
Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03313895 (Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Efficacy and Mechanisms of Combined Aerobic Exercise and Cognitive Training (ACT) in MCI
Who cites it
1 citing paper in PubMed.
- Efficacy of sequential aerobic exercise and cognitive training in older adults with amnestic mild cognitive impairment.Aging and health research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Implementing multi-site behavioral intervention trials to study Alzheimer's disease (AD) has many unique challenges, leading to substantial variations in delivered intervention doses and cognitive findings. These issues can be addressed by the IMplementation Framework fOr Behavioral and LIfestyLe Interventions In AlZheimer's DiseasE (MOBILIZE), which was developed to guide the design and implementation of behavioral interventions in AD. Building on the person-centered principle, MOBILIZE includes three implementation outcomes with corresponding team processes: (1) screening (processes), (2) intervention adherence (processes), and (3) safety (processes). This study systematically evaluated MOBILIZE implementation outcomes of the 3-site aerobic exercise and cognitive training (ACT) Trial (recruitment started on 4/1/2018 and last follow-up on 7/17/2024). Outcomes included time in screening phases, intervention adherence (attendance and intervention dose adherence, and safety [adverse events]). Sample (n = 146) was 73.8 ± 5.7 years in age and 23.4 ± 2.1 on Montreal Cognitive Assessment score, with 48.0% female and 91.8% White. The median days of screening-to-enrollment averaged 98 days. Attendance was 76.7 ± 28.6%. Adherence to 100% exercise session dose and 100% cognitive session dose was 71.7 ± 30.8% and 51.5 ± 26.2%, respectively. There were 10 study-related adverse events. MOBILIZE helped the ACT Trial achieve high intervention attendance and safety and may be important for early-stage trials in AD.Trial registration The ACT Trial is registered at clinicaltrials.gov (NCT03313895). Registered 15 July 2017, https://clinicaltrials.gov/study/NCT03313895 .
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