Evidence map›Paper›PMID 39948331›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

The Mechanistic Study of Mitochondrial Autophagy and Ferroptosis in the Progression of Decreased Ovarian Reserve.

Qianwen Ma, Lifei Wu, Jianfei Wu, Binfei Ni, Jiajia Wang, Shiyan Song

Abstract read
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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qianwen MaTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China. 185849087@qq.com.ORCID 0000-0003-2419-2951
Lifei WuSports Department, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Jianfei WuTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China.
Binfei NiTCM Department, Hangzhou Ninth People's Hospital, Number 98, Yilong Road, Yipeng Street, Qiantang District, Hangzhou, 311225, Zhejiang, China.
Jiajia WangTCM Department, Hospital of Taizhou, Number 150, Ximen Street, Taizhou, 317000, Zhejiang, China. wangjj6604@enzemed.com.
Shiyan SongGynecology Department, Nanjing Hospital of Chinese Medicine, Number 157, Daming Road, Qinhuai District, Nanjing, 210000, Jiangsu, China. songshiyan19891123@163.com.

Funding

National Natural Science Foundation 82405452Zhejiang Provincial Natural Science Foundation LQ23H270018Zhejiang Technology Program Project of Medicine and Health Science 2023RC071Zhejiang Technology Program Project of Traditional Chinese Medicine 2023ZL127
6 · The paper itself

Abstract

objectiveTo investigate the mechanism in the progression of decreased ovarian reserve (DOR).

methodsThree-month-old female SD rats were employed and randomly divided into the model group and the normal group. The model group was intraperitoneally injected with 4-vinylcyclohexene diepoxide (VCD). Thereafter, blood sample from the abdominal aorta was taken, and rats were sacrificed, and ovarian tissues were obtained by laparotomy.

resultsHE staining results revealed that the model group exhibited significantly reduced ovarian volume, increased follicular atresia, and decreased quantities of growing follicles and corpus luteum, thereby indicating degraded reserve function of ovarian. TEM images revealed that prominent autophagic vacuoles could be observed in the model group, accompanied by the mitochondria shrinkage and generation of the autophagosome. The expression of Pink1, Parkin, BNIP3L and LC3II genes in ovaries of the model group was significantly higher than those of the normal group (P < 0.05). In addition, the protein expression of Pink1, Parkin, BNIP3L and LC3II in ovaries of the model group were higher than those of the normal group (P < 0.05). The expression of Fe

conclusionsMitochondrial autophagy and ferroptosis may participate in the progression of decreased ovarian reserve (DOR).

Indexed as

AutophagyFerroptosisMitochondriaOvarian ReserveOvaryAnimalsCyclohexenesDisease ProgressionFemaleProtein KinasesPTEN-Induced Putative KinaseRatsRats, Sprague-DawleyUbiquitin-Protein LigasesVinyl Compounds4-vinyl-1-cyclohexene dioxideCyclohexenesparkin proteinProtein KinasesPTEN-Induced Putative KinaseUbiquitin-Protein LigasesVinyl CompoundsDecreased ovarian reserveFerroptosisFollicleMechanistic studyMitochondrial autophagy

Identifiers

PMID39948331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.