Evidence map›Paper›PMID 39948263›Full record

ArticleSurgical endoscopy2025

Comparison of laparoscopic and open gastrectomy after neoadjuvant chemotherapy for locally advanced gastric cancer: a propensity score matching analysis.

Keijiro Sugimura, Masaaki Motoori, Kishi Kentaro, Kazuyoshi Yamamoto, Atsushi Takeno, Hisashi Hara, Takuya Hamakawa, Kohei Murakami, Yujiro Nakahara, Toru Masuzawa and 4 more

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Keijiro SugimuraDepartment of Surgery, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan. sugimura-keijiro@kansaih.johas.go.jp.ORCID 0000-0002-5100-9377
Masaaki MotooriDepartment of Surgery, Osaka General Medical Center, Osaka, Japan.
Kishi KentaroDepartment of Surgery, Osaka Police Hospital, Osaka, Japan.
Kazuyoshi YamamotoDepartments of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Atsushi TakenoDepartment of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
Hisashi HaraDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Takuya HamakawaDepartment of Surgery, National Hospital Organization, Osaka National Hospital, Osaka, Japan.
Kohei MurakamiDepartment of Surgery, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan.
Yujiro NakaharaDepartment of Surgery, Osaka Police Hospital, Osaka, Japan.
Toru MasuzawaDepartment of Surgery, Kansai Rosai Hospital, 3-1-69 Inabaso, Amagasaki, Hyogo, 660-8511, Japan.
Takeshi OmoriDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, Osaka, Japan.
Yukinori KurokawaDepartments of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Kazumasa FujitaniDepartment of Surgery, Osaka General Medical Center, Osaka, Japan.
Yuichiro DokiDepartments of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the safety and efficacy of laparoscopic gastrectomy (LG) in patients with locally advanced gastric cancer who underwent neoadjuvant chemotherapy (NAC).

methodsThis study included 247 consecutive patients with advanced gastric cancer who underwent NAC followed by gastrectomy between 2007 and 2017 at one of six institutions. The patients were divided into the open gastrectomy (OG) and LG groups. The short- and long-term outcomes in both groups were investigated after propensity score matching.

resultsAfter propensity score matching, 72 pairs of patients were selected. The baseline characteristics were not significantly different after matching. Compared with the OG group, the LG group had a significantly longer operative time (360 vs. 305 min, P = 0.002) and less intraoperative blood loss (271 vs. 652 mL, P < 0.001). The LG group had more harvested lymph nodes than the OG group (57.4 vs. 45.1, P < 0.001). The frequency of Clavien-Dindo grade ≥ 2 postoperative complications was not significantly different (26% vs. 22%, P = 0.698). The interval between surgery and postoperative chemotherapy was significantly shorter in the LG group (48.7 vs. 68.6 days, P = 0.048). The 5-year overall survival rates in the OG and LG groups were 54.4% and 53.5%, respectively. The overall survival was similar between the two groups (P = 0.773). No significant differences were observed between the two groups in terms of the type of recurrence, including lymph node, hematogenous, and peritoneal recurrences (P = 1.000, P = 1.000, and P = 0.686, respectively).

conclusionsBased on both short- and long-term results, LG is a potential therapeutic option for patients with gastric cancer who undergo NAC.

Indexed as

GastrectomyLaparoscopyStomach NeoplasmsAdultAgedBlood Loss, SurgicalChemotherapy, AdjuvantFemaleHumansLymph Node ExcisionMaleMiddle AgedNeoadjuvant TherapyOperative TimePostoperative ComplicationsPropensity ScoreGastric cancerLaparoscopic gastrectomyNeoadjuvant chemotherapyOpen gastrectomy

Identifiers

PMID39948263

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.