SynthesisHypertension research : official journal of the Japanese Society of Hypertension2025
Effect of intensive versus standard blood pressure control on cardiovascular outcomes in adult patients with hypertension: a systematic review and meta-analysis.
Synthesis in Hypertension research : official journal of the Japanese Society of Hypertension, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of intensive versus standard blood pressure control on cardiovascular outcomes: a meta-analysis of randomized controlled trials.Annals of medicine · 2026Pooled it
- Intensive blood pressure lowering across metabolic syndrome severity: balancing absolute benefits and relative effects.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- What is "Implementation Hypertension"? Uniting individuals, healthcare, and society around blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Risk of falls and syncope across frailty levels in hypertensive older adults: a longitudinal study.GeroScience · 2026Article
- The conservative-challenging paradigm of antihypertensive therapy in JSH2025: a comparative perspective with contemporary Western guidelines.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Advancing evidence-based blood pressure targets in JSH2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- The new blood pressure target, a new era: individualized management and precision rooted in clinical decision in JSH2025.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- The JSH Morning Hypertension Eradication Program Project.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Achievement rate of blood pressure control <130/80 mmHg as the core metric of implementation hypertension, based on the new JSH2025 and AHA/ACC2025 guidelines.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- JSH2025 guidelines new viewpoints.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Key highlights of the Japanese Society of Hypertension Guidelines for the management of elevated blood pressure and hypertension 2025 (JSH2025).Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a systematic review and meta-analysis to evaluate the effects of intensive versus standard antihypertensive therapy on cardiovascular outcomes in adult patients with hypertension. The primary endpoints were composite cardiovascular events, all-cause death, cardiovascular death, and serious adverse events. The secondary endpoints included cognitive impairment, hypotension, syncope, acute kidney injury, and composite renal outcomes. Eight trials classifying a systolic blood pressure (SBP) target of <130 mmHg as intensive control was adopted in the primary analysis. The intensive blood pressure (BP) control significantly reduced the relative risk (RR) for cardiovascular events and cardiovascular death compared to standard BP control (RR 0.83 [95% confidence interval, 0.76-0.90] and 0.74 [0.56-0.97], respectively). The intensive BP control tended to reduce the RR for all-cause death, but not significant (0.89 [0.78-1.02]). On the other hand, the intensive BP control significantly increased the RR for serious adverse events, hypotension, and syncope (1.59 [1.19-2.12], 1.96 [1.04-3.70], and 2.36 [1.95-2.85], respectively). The intensive BP control significantly increased the RR for acute kidney injury (2.65 [1.78-3.95]), but did not affect for composite renal outcomes (1.38 [0.83-2.31]). For cognitive impairment, no significant increase or decrease in risk was observed (0.93 [0.68-1.26]). Based on these findings, we recommend the intensive BP control targeting SBP below 130 mmHg to achieve significant reductions in cardiovascular events and cardiovascular death, accompanied by careful monitoring for potential adverse events including acute kidney injury, hypotension, syncope related with the intensive BP control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.