ArticleScientific reports2025
miRNA sequencing identifies immune-associated miRNAs and highlights the role of miR-193b-5p in sepsis and septic shock progression.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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Who cites it
7 citing papers in PubMed.
- MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring.World journal of critical care medicine · 2026Review
- Updates on the role of miR-193b in the pathogenesis of human cancers and other diseases.Biochemistry and biophysics reports · 2026Review
- Lymphocyte function inhibition and exhaustion in sepsis: mechanisms and applications.Frontiers in immunology · 2026Review
- Review
- Regulatory effect of miR-142-5p on inflammatory process of sepsis by targeting CXCL8.Hereditas · 2025Article
- GSK-3α regulates miRNAs associated with transcriptional and metabolic processes in human cardiomyocytes under hypoxia.The Biochemical journal · 2025Article
- Immunothrombosis in Sepsis: Cellular Crosstalk, Molecular Triggers, and Therapeutic Opportunities-A Review.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
This study aimed to evaluate the diagnostic value of miR-193b-5p and miR-511-5p in sepsis and septic shock from the perspective of immune regulation. Initially, serum exosomal miRNA sequencing was conducted on patients with sepsis (n = 6), septic shock (n = 6), and healthy controls (n = 3). Using bioinformatics analysis, miR-193b-5p and miR-511-5p were identified as immune-related miRNAs differentiating sepsis from septic shock. Subsequently, quantitative real-time polymerase chain reaction (qRT-PCR) was performed to validate the identified miRNAs in a cohort of 90 participants, including 30 patients with sepsis, 30 with septic shock, and 30 general surgery patients serving as controls. The results indicated that miR-193b-5p expression level was significantly reduced in septic patients and septic shock patients compared with healthy controls. Both miR-193b-5p and miR-511-5p exhibited diagnostic potential, distinguishing sepsis from the control group, with area under the curve values of 0.797 and 0.795, respectively (P < 0.05). Furthermore, miR-193b-5p expression level was inversely correlated with C-reactive protein level (r = -0.40, P < 0.001), procalcitonin level (r = -0.31, P = 0.003), and interleukin-6 level (r = -0.39, P < 0.001). A positive correlation was identified between miR-193b-5p and lymphocyte count (r = 0.26, P = 0.014). In conclusion, serum miR-193b-5p demonstrated potential as a diagnostic biomarker for sepsis and was associated with inflammation and immune regulation in sepsis.
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Registered trials
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