Evidence map›Paper›PMID 39948108›Full record

ArticleNPJ microgravity2025

Plyometric training increases thickness and volume of knee articular cartilage in mice.

Marco Chiaberge, Neelima Thottappillil, Anna-Maria Liphardt, Anderson Furlanetto, Dylan Odell, Christine Wang, Stephen Hope, Stephen Smee, Joseph Rehfus, Anja Niehoff and 6 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Marco ChiabergeThe William H. Miller III Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, USA. marcoc@stsci.edu.ORCID http://orcid.org/0000-0003-1564-3802
Neelima ThottappillilDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Anna-Maria LiphardtDepartment of Internal Medicine 3-Rheumatology and Immunology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany.ORCID http://orcid.org/0000-0003-0739-1959
Anderson FurlanettoDepartment of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Dylan OdellDepartment of Neuroscience, Johns Hopkins University, Baltimore, MD, USA.
Christine WangDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Stephen HopeThe William H. Miller III Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, USA.
Stephen SmeeThe William H. Miller III Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, USA.
Joseph RehfusDepartment of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.
Anja NiehoffInstitute of Biomechanics and Orthopaedics, German Sport University Cologne, Köln, Germany.
Mark ShelhamerHuman Spaceflight Lab, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Colin NormanThe William H. Miller III Department of Physics & Astronomy, Johns Hopkins University, Baltimore, MD, USA.
Marc J PhilipponSteadman Philippon Research Institute, Vail, CO, USA.
Johnny HuardSteadman Philippon Research Institute, Vail, CO, USA.
Aaron W JamesDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Chen-Ming FanDepartment of Biology, Johns Hopkins University, Baltimore, MD, 21218, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degeneration and thinning of articular cartilage lead to osteoarthritis and may result from reduced joint loading during e.g. bed rest or as a result of microgravity during space flight. Anabolic physical exercises for cartilage are not well studied to date. We built an experimental apparatus for plyometric training with mice to test potential benefits of jumping for articular cartilage. The exercise group (JUMP) performed jump training for 9 weeks and was compared with sedentary mice (control, CON) and hindlimb-suspended (HLS) mice (to simulate reduced loading) for the same duration. Knee cartilage was assessed via 3-dimensional reconstruction of micro-CT scans and histology. We observed significant thinning and volume reduction of articular cartilage at the medial tibial-femoral point of contact in the HLS group. Clustering of chondrocytes was present in HLS. By contrast, the JUMP group showed both cartilage thickening and volume increase. We observed a similar trend on trabecular bone thickness and volume. Our results show that plyometric training can stimulate cartilage thickness and volume in mice. This suggests further investigation of this mode of exercise as a countermeasure to prevent cartilage atrophy in disuse scenarios such as long duration spaceflight, and for patients at risk of developing osteoarthritis.

Identifiers

PMID39948108
PMCPMC11825961

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.