Evidence map›Paper›PMID 39948065›Full record

ArticleNature communications2025

Pesticides have negative effects on non-target organisms.

Nian-Feng Wan, Liwan Fu, Matteo Dainese, Lars Pødenphant Kiær, Yue-Qing Hu, Fengfei Xin, Dave Goulson, Ben A Woodcock, Adam J Vanbergen, David J Spurgeon and 2 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

85 citing papers in PubMed.

  1. Review
  2. Review
  3. Biotechnological valorization of rice waste from Trichoderma production through the development of a streptomyces-based biological soil conditioner.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  4. Article
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  7. Article
  8. Biosynthetic diversity and antifungal potential of soil-derivedApplied and environmental microbiology · 2026
    Article
  9. 2'-Deoxyuridine-promoted infection inApplied and environmental microbiology · 2026
    Article
  10. Dual-line Genome-scale CRISPR Screening Enables Robust Target Gene Discovery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
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  18. Article
  19. Article
  20. Article

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Nian-Feng Wan *Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, China. nfwan@ecust.edu.cn.ORCID http://orcid.org/0000-0001-9486-9150
Liwan Fu *Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.ORCID http://orcid.org/0000-0002-7851-6379
Matteo DaineseDepartment of Biotechnology, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-7052-5572
Lars Pødenphant KiærDepartment of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.ORCID http://orcid.org/0000-0002-1501-8831
Yue-Qing HuState Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-5730-0317
Fengfei XinWetland Research Department, Shanghai Wildlife and Protected Natural Areas Research Center, Shanghai, China.ORCID http://orcid.org/0000-0002-6718-8250
Dave GoulsonSchool of Life Sciences, University of Sussex, Brighton, UK.ORCID http://orcid.org/0000-0003-4421-2876
Ben A WoodcockUK Centre for Ecology and Hydrology, Wallingford, UK.ORCID http://orcid.org/0000-0003-0300-9951
Adam J VanbergenAgroécologie, INRAE, Institut Agro, Université de Bourgogne, Université Bourgogne Franche-Comté, Dijon, France.ORCID http://orcid.org/0000-0001-8320-5535
David J SpurgeonUK Centre for Ecology and Hydrology, Wallingford, UK.ORCID http://orcid.org/0000-0003-3264-8760
Siyuan ShenState Key Laboratory of Genetic Engineering, Institute of Biostatistics, School of Life Sciences, Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0002-4131-3607
Christoph ScherberCentre for Biodiversity Monitoring and Conservation Science, Leibniz Institute for the Analysis of Biodiversity Change, Museum Koenig, Bonn, Germany.ORCID http://orcid.org/0000-0001-7924-8911

Funding

National Natural Science Foundation of China (National Science Foundation of China) 11971117National Natural Science Foundation of China (National Science Foundation of China) 32172484National Natural Science Foundation of China (National Science Foundation of China) 82204063
6 · The paper itself

Abstract

Pesticides affect a diverse range of non-target species and may be linked to global biodiversity loss. The magnitude of this hazard remains only partially understood. We present a synthesis of pesticide (insecticide, herbicide and fungicide) impacts on multiple non-target organisms across trophic levels based on 20,212 effect sizes from 1,705 studies. For non-target plants, animals (invertebrate and vertebrates) and microorganisms (bacteria and fungi), we show negative responses of the growth, reproduction, behaviour and other physiological biomarkers within terrestrial and aquatic systems. Pesticides formulated for specific taxa negatively affected non-target groups, e.g. insecticidal neonicotinoids affecting amphibians. Negative effects were more pronounced in temperate than tropical regions but were consistent between aquatic and terrestrial environments, even after correcting for field-realistic terrestrial and environmentally relevant exposure scenarios. Our results question the sustainability of current pesticide use and support the need for enhanced risk assessments to reduce risks to biodiversity and ecosystems.

Indexed as

PesticidesAnimalsBacteriaBiodiversityEcosystemFungiInsecticidesInvertebratesPlantsInsecticidesPesticides

Identifiers

PMID39948065
PMCPMC11825942

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.