Evidence map›Paper›PMID 39947922›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2025

Stimulus-Dependent Expression of

Eli-Eelika Esvald, Andra Moistus, Karin Lehe, Annela Avarlaid, Anastassia Šubina, Liis Kuusemets, Jürgen Tuvikene, Tõnis Timmusk

Abstract read
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In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Stimulus-Dependent Expression ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Eli-Eelika EsvaldDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.ORCID 0000-0001-5730-8207
Andra MoistusDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Karin LeheDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Annela AvarlaidDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Anastassia ŠubinaDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Liis KuusemetsDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.
Jürgen TuvikeneDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia.ORCID 0000-0002-9665-760X
Tõnis TimmuskDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn 12618, Estonia tonis.timmusk@taltech.ee.ORCID 0000-0002-1015-3348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurotrophins like BDNF have a key role in the proper functioning of the central nervous system, influencing numerous processes like memory formation and behavior. An imbalance in BDNF levels can lead to a wide range of diseases, including depression and neurodevelopmental disorders. While the potential therapeutic effects of BDNF are well-recognized, there is a knowledge gap in understanding the mechanisms governing BDNF expression levels. Here, we focused on the regulation of

Indexed as

Activating Transcription Factor 2Brain-Derived Neurotrophic FactorEarly Growth Response Protein 1Gene Expression RegulationTranscription FactorsAnimalsCells, CulturedFemaleHippocampusMaleNeuronsRatsRats, Sprague-DawleyReceptor, trkBSignal TransductionActivating Transcription Factor 2Bdnf protein, ratBrain-Derived Neurotrophic FactorEarly Growth Response Protein 1Egr1 protein, ratReceptor, trkBTranscription FactorsATF2BDNF-TrkB signalingEGR familyMYT1Lneuronal activity

Identifiers

PMID39947922
PMCPMC11924897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.