Evidence map›Paper›PMID 39947917›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

Full-Body Tumor Response Heterogeneity of Metastatic Neuroendocrine Tumor Patients Undergoing Peptide Receptor Radiopharmaceutical Therapy.

Victor Santoro-Fernandes, Brayden Schott, Amy J Weisman, Ojaswita Lokre, Steve Y Cho, Scott B Perlman, Timothy G Perk, Robert Jeraj

Abstract read
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Prognostic value and diagnostic performance of nectin-4-targeted [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Immune Checkpoint Blockade Enhances the Abscopal Effect of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor Santoro-FernandesDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Brayden SchottDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.
Amy J WeismanAIQ Solutions, Madison, Wisconsin.
Ojaswita LokreAIQ Solutions, Madison, Wisconsin.
Steve Y ChoSection of Nuclear Medicine and Molecular Imaging, Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and.
Scott B PerlmanSection of Nuclear Medicine and Molecular Imaging, Department of Radiology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; and.
Timothy G PerkAIQ Solutions, Madison, Wisconsin.
Robert JerajDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; rjeraj@wisc.edu.

Funding

University of Wisconsin Prostate SPOREP50CA269011 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI DAVID F. JARRARD, DOUGLAS G. MCNEEL · 2023 to 2026
$10.6M
NCI NIH HHS P50 CA269011
6 · The paper itself

Abstract

Patients with metastatic neuroendocrine tumors (NETs) can present with hundreds of lesions, and each lesion might have a unique response pattern to peptide receptor radiopharmaceutical therapy (PRRT). This response heterogeneity has been observed but is poorly understood. In this work, we perform a quantitative analysis of longitudinal PET/CT scans to comprehensively characterize the NET response to PRRT.

Indexed as

Neuroendocrine TumorsOctreotideRadiopharmaceuticalsReceptors, PeptideAdultAgedFemaleHumansMaleMiddle AgedNeoplasm MetastasisOrganometallic CompoundsPositron Emission Tomography Computed TomographyRetrospective StudiesTreatment Outcomelutetium Lu 177 dotatateOctreotideOrganometallic CompoundsRadiopharmaceuticalsReceptors, Peptideneuroendocrine tumorpeptide receptor radiopharmaceutical therapyPET/CTresponse heterogeneitytheranosticstreatment response assessment

Identifiers

PMID39947917
PMCPMC12782047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.