Evidence map›Paper›PMID 39947352›Full record

ArticleBioorganic & medicinal chemistry letters2025

Synthesis and evaluation of a novel bifunctional ligand 3o-C-NETA for Yttrium-90 and Lutetium-177.

Hua Xu, Pengfei Dong, Haixing Wang, Inseok Sin, Chi Soo Kang, Siyuan Ren, Xiang Sun, Hyun-Soon Chong

Abstract read
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hua XuDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Pengfei DongDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Haixing WangDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Inseok SinDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Chi Soo KangDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Siyuan RenDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Xiang SunDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States.
Hyun-Soon ChongDepartment of Chemistry, Lewis College of Science and Letters, Illinois Institute of Technology, Chicago, IL, United States. Electronic address: chong@iit.edu.

Funding

XRAY CRYSTALLOGRAPHIC STRUCTURE ANALYSIS: PROTEIN SORTINGP41RR001081 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 1985 to 2011
$17.6M
New Bifunctional Ligands for RadioimmunotherapyR01CA112503 · NCI · ILLINOIS INSTITUTE OF TECHNOLOGY · PI CHONG, HYUN-SOON · 2006 to 2017
$2.0M
NCI NIH HHS R01 CA112503NCRR NIH HHS P41 RR001081
6 · The paper itself

Abstract

A bifunctional ligand is an essential component for targeted cancer therapy using cytotoxic radionuclides. We report the synthesis and evaluation of a novel bifunctional ligand, 3o-C-NETA, designed for labeling a bioactive small molecule or an antibody with β-particle emitting radionuclides

Indexed as

LutetiumRadioisotopesYttrium RadioisotopesChelating AgentsHeterocyclic CompoundsHumansLigandsMolecular StructureRadiopharmaceuticals1,4,7-triazacyclononaneChelating AgentsHeterocyclic CompoundsLigandsLutetiumLutetium-177RadioisotopesRadiopharmaceuticalsYttrium-90Yttrium RadioisotopesBifunctional chelatorLutetium-177Yttrium-90

Identifiers

PMID39947352
PMCPMC12085980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.