Observational studyHormone research in paediatrics2026
Hypothyroidism in Infants after Enteral Administration of Iodinated Contrast Media: A Rare but Serious Complication.
Observational study in Hormone research in paediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The effect of iodinated contrast media on thyroid (dys)function in children.European thyroid journal · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionExcessive exposure to iodine early in life can cause primary hypothyroidism by failure to escape the Wolff-Chaikoff effect. Although reported for intravenous iodinated contrast medium (ICM) and topical iodine, prospective studies on thyroid function after enterally administered ICM are lacking. This study aimed to determine the occurrence of hypothyroidism after enteral ICM administration in young infants.
methodsProspective cohort study was conducted between November 1st, 2022, and July 1st, 2024, in infants <6 months of age, who underwent radiological examination (mostly abdominal X-ray, AXR) with enteral ICM administration. Stasis of contrast was evaluated by AXR on day two after ICM administration. Serum thyroid-stimulating hormone (TSH) and free thyroxine (fT4) levels were measured around days 5 and 10 after ICM administration and, if abnormal, repeated on day 15.
resultsThirty-three patients were included. Seventeen patients (51.5%) were born preterm. Stasis of ICM after 2 days was present in 12 of 28 patients (42.9%). In 5 male patients (15.2%), abnormal TSH or fT4 levels were observed during follow-up. One of these 5 patients developed ICM-induced hypothyroidism requiring treatment. In 2 cases, physiological escape of the Wolff-Chaikoff effect was seen. In 2 cases, non-thyroidal illness/hypothyroxinemia of prematurity was observed. Four of the 5 patients with abnormal TSH or fT4 levels were born preterm.
conclusionIn this study, 1 patient developed primary hypothyroidism requiring levothyroxine treatment after enteral ICM administration. We recommend monitoring of thyroid function in infants younger than 6 months after enteral ICM administration, especially in preterm born infants.
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