Evidence map›Paper›PMID 39946537›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex.

Fangming Xie, Saumya Jain, Runzhe Xu, Salwan Butrus, Zhiqun Tan, Xiangmin Xu, Karthik Shekhar, S Lawrence Zipursky

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Establishing a continuum of cell types in the visual cortex.bioRxiv : the preprint server for biology · 2025
    Article
  7. Neural Circuit Mapping and Neurotherapy-Based Strategies.Cellular and molecular neurobiology · 2025
    Review
  8. Article
  9. Article
  10. Spatial profiling of the interplay between cell type- and vision-dependent transcriptomic programs in the visual cortex.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Fangming Xie *Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.ORCID 0000-0001-5232-1648
Saumya Jain *Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Runzhe Xu *Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
Salwan ButrusDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
Zhiqun TanDepartment of Anatomy and Neurobiology, Center for Neural Circuit Mapping, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.ORCID 0000-0002-2235-4577
Xiangmin XuDepartment of Anatomy and Neurobiology, Center for Neural Circuit Mapping, Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.
Karthik ShekharDepartment of Chemical and Biomolecular Engineering, University of California, Berkeley, CA 94720.
S Lawrence ZipurskyDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.

Funding

Origins of plasticity in the establishment of binocular visionR01EY023871 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Joshua Trachtenberg · 2013 to 2026
$5.4M
Thalamic constraints on cortical organizationR01EY034488 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RINGACH, DARIO L · 2023 to 2025
$1.8M
Population codes and sensory discriminationR01NS116471 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RINGACH, DARIO L · 2023 to 2024
$789k
Visual function of transcriptomically defined glutamatergic neuronsR21EY036219 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RINGACH, DARIO L · 2024 to 2025
$426k
Single-cell Transcriptomic Analysis of Cell Type Plasticity in Barrel Cortex of Normal and Autism Model MiceF31NS131016 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BUTRUS, SALWAN · 2023 to 2024
$90k
NEI NIH HHS R01 EY023871NEI NIH HHS R01 EY034488NEI NIH HHS R21 EY036219NINDS NIH HHS F31 NS131016NINDS NIH HHS R01 NS116471W. M. Keck Foundation (WMKF) xx
6 · The paper itself

Abstract

How early sensory experience during "critical periods" of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previously reported that the functional and molecular profiles of layer 2/3 (L2/3) cell types in the primary visual cortex (V1) are vision-dependent [S. Cheng

Indexed as

NeuronsPrimary Visual CortexTranscriptomeVision, OcularVisual CortexAnimalsGene Expression ProfilingMicecortexgradientsspatial transcriptomicstranscriptomicsvision

Identifiers

PMID39946537
PMCPMC11848306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.