ArticleProceedings of the National Academy of Sciences of the United States of America2025
Raver1 links
Abstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of cellular phosphoproteome datasets exploring phospho-signaling associated with the RNA-binding protein RAVER1.Scientific reports · 2026Pooled it
- PANoptosis in the pathogenesis of myelodysplastic syndromes.Molecular oncology · 2026Review
- Programmed cell death in cancer: targeting necroptosis to kill tumor cell.Cell death discovery · 2026Review
- CD95 ligand drives abdominal aortic aneurysm progression through Caspase-8-mediated GSDMD-dependent endothelial pyroptosis: modulation by SRC kinase.Apoptosis : an international journal on programmed cell death · 2026Article
- Exploring genetic loci linked to COVID-19 severity and immune response through multi-trait GWAS analyses.Frontiers in genetics · 2025Article
Corrections and comments
- Update ofRaver1 links2024
Authors and funding
16 authors.
Boyao Zhang *Division of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0009-0008-4371-005X
Pontus Orning *Division of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Jesse W LehmanRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-3729-2866
Alexandre DinisDivision of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Leslie Torres-UlloaRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655.
Roland EllingInstitute for Immunodeficiency, Center of Chronic Immunodeficiency, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.
Michelle A KelliherDepartment of Molecular Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0001-9211-3659
John BertinPattern Recognition Receptor Discovery Performance Unit, Immuno-Inflammation Therapeutic Area, GlaxoSmithKline, Collegeville, PA 19426.
Megan K ProulxDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-9524-8302
Jon D GoguenDepartment of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01655.
Liv RyanDepartment of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Richard K KandasamyDivision of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.
Terje EspevikDepartment of Clinical and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Athma A PaiRNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01655.ORCID 0000-0002-7995-9948
Katherine A FitzgeraldDivision of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0003-3175-609X
Egil LienDivision of Infectious Diseases and Immunology, Department of Medicine, Program in Innate Immunity, University of Massachusetts Chan Medical School, Worcester, MA 01605.ORCID 0000-0002-8536-2419
Funding
Mechanism(s) of TAL-1/SCL-mediated LeukemogenesisR01CA096899 · NCI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MICHELLE ALICE KELLIHER · 2004 to 2026
$6.9MGene Regulation in Innate ImmunityR37AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2015 to 2024
$4.6MTracking transcriptome diversity in real-timeR35GM133762 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Athma A Pai · 2019 to 2026
$3.3MCaspase-8 as a focal hub in effector-triggered immunityR01AI146855 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2019 to 2023
$2.9MInnate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5MRNA splicing factor Raver1 controls cell death, inflammation, and innateimmunityR01AI181309 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Egil Lien · 2024 to 2026
$2.5MRole of PISA; a PYHIN Family Member in Intracellular DNA RecognitionR01AI083713 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A., LATZ, EICKE · 2009 to 2013
$2.0MRegulation of Type I Interferon Gene Expression in the Innate Immune ResponseR01AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2006 to 2010
$2.0MThe role of LPS-TLR4 signaling in live vaccine-induced protective responsesR01AI075318 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2009 to 2013
$1.9MBacterial activation and evasion of a PP2A phosphatase – Pyrin - Gasdermin D axisR21AI159706 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2021 to 2022
$461kThe role of LPS-TLR4 signaling in live vaccine-induced protective responsesR56AI075318 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LIEN, EGIL · 2008 to 2008
$430kRegulation of Type I Interferon Gene Expression in the Innate Immune ResponseR56AI067497 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FITZGERALD, KATHERINE A. · 2012 to 2012
$415kHHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI067497HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI075318HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI075811HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI083713HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI095213HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI129527HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI159706HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI181309HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM133762HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM133762 (diversity supplement)NCI NIH HHS R01 CA096899NIAID NIH HHS R01 AI067497NIAID NIH HHS R01 AI075318NIAID NIH HHS R01 AI083713NIAID NIH HHS R01 AI146855NIAID NIH HHS R01 AI181309NIAID NIH HHS R21 AI159706NIAID NIH HHS R37 AI067497NIAID NIH HHS R56 AI067497NIAID NIH HHS R56 AI075318NIAID NIH HHS T32 AI095213NIGMS NIH HHS R35 GM133762Norwegian Cancer Society B05035/001Research Council of Norway, Center of Excellence Funding Scheme project 223255/F50
Abstract
Multiple cell death and inflammatory signaling pathways converge on two critical factors: receptor-interacting serine/threonine kinase 1 (RIPK1) and caspase-8. Careful regulation of these molecules is critical to control apoptosis, pyroptosis, and inflammation. Here, we found a pivotal role of Raver1 as an essential regulator of
Indexed as
Caspase 8InflammationPyroptosisReceptor-Interacting Protein Serine-Threonine KinasesRNA-Binding ProteinsRNA SplicingAnimalsCell DeathDisease ResistanceMacrophagesMiceMice, Inbred C57BLMice, KnockoutSignal TransductionYersinia InfectionsCasp8 protein, mouseCaspase 8Receptor-Interacting Protein Serine-Threonine KinasesRipk1 protein, mouseRNA-Binding Proteinscaspase-8gasderminIL-1ßpyroptosisRIPK1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.