Evidence map›Paper›PMID 39946531›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogen

Ryan M Wyllie, Paul A Jensen

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. From predicted bacteriocins to ecological function.Current research in microbial sciences · 2026
    Review
  2. Review
  3. Review
  4. AJournal of bacteriology · 2026
    Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ryan M WyllieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.
Paul A JensenDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109.ORCID 0000-0002-1257-9836

Funding

Microbial multi-stress responses: from intracellular networks to communities - Equipment SupplementR35GM138210 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JENSEN, PAUL ANTHONY · 2020 to 2024
$2.0M
HHS | National Institutes of Health (NIH) GM138210NIGMS NIH HHS R35 GM138210
6 · The paper itself

Abstract

Microbes use quorum-sensing systems to respond to ecological and environmental changes. In the oral microbiome, the pathogenic bacterium

Indexed as

Bacterial ProteinsBacteriocinsQuorum SensingStreptococcus mutansGene Expression Regulation, BacterialHumansBacterial ProteinsBacteriocinsbacteriocinspeptide pheromonesquorum-sensingStreptococcus mutans

Identifiers

PMID39946531
PMCPMC11848300

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.