ArticleScience (New York, N.Y.)2025
KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
54 citing papers in PubMed.
- Contrasting functions of CD73 and adenosine in CD8+ T-cell exhaustion during antitumor immunity.Oncoimmunology · 2026Article
- Article
- Characterizing and mitigating cross-library PCR chimeras in Perturb-seq using Perturb-Audit.Blood science (Baltimore, Md.) · 2026Article
- High-Content CRISPR Screening: Methods and Applications.MedComm · 2026Review
- DUSP4 promotes anti-tumor CD8Nature communications · 2026Article
- Article
- Multiscale learning of gene network-driven phenotypic dynamics of single cells.Molecular systems biology · 2026Article
- T-cell miR-155 regulates the response to tumor-specific mRNA vaccines in a murine model of acute myeloid leukemia.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nature immunology · 2026Article
- New insights into progenitor exhausted T cell populations.Nature reviews. Immunology · 2026Article
- Single-cell gain-of-function mapping reveals latent regulatory programs governing CD8Research square · 2026Article
- Systemic pre-conditioning favors effector over exhausted CD8 T-cell subsets following Sup2-IL33 armored CAR T-cell therapy.Journal for immunotherapy of cancer · 2026Article
- Generation of CCR4/CD7 Bispecific CAR-T Cells Resistant to Fratricide and Exhaustion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regulation of T Cell Senescence in Health and Diseases.Immune network · 2026Review
- KLF4 overexpression in CAR T cells enhances antitumor potency by preventing exhaustion.Journal for immunotherapy of cancer · 2026Article
- Krüppel-like factors 2 and 3 regulate T cell exhaustion by directing T cell residency and migration.Immunity · 2026Article
- Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.bioRxiv : the preprint server for biology · 2026Article
- Transcription factor collaboration enables precise T cell state engineering.bioRxiv : the preprint server for biology · 2026Article
- Functions and features of circulating memory T cells.Immunity · 2026Review
- Rational redesign of antigen binding domain improves in vivo efficacy of the CD22-CAR.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors.
Eric FagerbergDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0313-3717
John AttanasioDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7498-1452
Christine DienDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0009-0008-8850-3046
Jaiveer SinghDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Emily A KesslerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2608-6020
Leena AbdullahDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0002-8077-7439
Jian ShenDepartment of Pathology, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.ORCID 0000-0001-8398-2318
Brian G HuntDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4155-730X
Kelli A ConnollyDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3403-1150
Edward De BrouwerDepartment of Genetics and Computer Science, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0608-0155
Jiaming HeDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-9494-3434
Nivedita R IyerDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0009-0006-9806-322X
Jessica BuckDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7586-364X
Emily R BorrDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Martina DamoDepartment of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-7217-3221
Gena G FosterSection of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3482-0579
Josephine R GilesDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-3713-338X
Yina H HuangDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0002-0125-9351
John S TsangDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3186-3047
Smita KrishnaswamyDepartment of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.ORCID 0000-0001-5823-1985
Weiguo CuiDepartment of Pathology, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA.ORCID 0000-0003-1562-9218
Nikhil S JoshiDepartment of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7045-7837
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MYale Pathology Tissue Services Shared ResourceP30CA016359 · NCI · YALE UNIVERSITY · PI Eric P. Winer · 1985 to 2026
$85.0MMEDICAL INFORMATICS RESEARCH TRAINING AT YALET15LM007056 · NLM · YALE UNIVERSITY · PI Mark Bender Gerstein, LUCILA OHNO-MACHADO · 1987 to 2026
$22.2MINTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4MTraining in Investigative DermatologyT32AR007016 · NIAMS · YALE UNIVERSITY · PI KEITH A CHOATE, MICHAEL GIRARDI · 1986 to 2026
$7.8MDrivers of individual variation in influenza vaccine response and protection from infectionR01AI170116 · NIAID · UNIVERSITY OF CHICAGO · PI Sarah Cobey, John S Tsang · 2022 to 2026
$7.2MDeveloping translationally-relevant genetically engineered mouse models of lung adenocarcinoma for investigations in cancer immunologyR01CA237037 · NCI · YALE UNIVERSITY · PI JOSHI, NIKHIL · 2020 to 2024
$2.7MHuman and Translational Immunology Training ProgramT32AI155387 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft, Kevan C Herold · 2021 to 2026
$2.6MFlow cytometer for high-parameter analysesS10OD026996 · OD · YALE UNIVERSITY · PI HABERMAN, ANN M · 2019 to 2019
$596kNCI NIH HHS P30 CA016359NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA237037NIAID NIH HHS R01 AI170116NIAID NIH HHS T32 AI007019NIAID NIH HHS T32 AI155387NIAMS NIH HHS T32 AR007016NIH HHS S10 OD026996NLM NIH HHS T15 LM007056
Abstract
Naïve CD8 T cells have the potential to differentiate into a spectrum of functional states during an immune response. How these developmental decisions are made and what mechanisms exist to suppress differentiation toward alternative fates remains unclear. We employed in vivo CRISPR-Cas9-based perturbation sequencing to assess the role of ~40 transcription factors (TFs) and epigenetic modulators in T cell fate decisions. Unexpectedly, we found that knockout of the TF
Indexed as
CD8-Positive T-LymphocytesKruppel-Like Transcription FactorsLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusT-Cell ExhaustionAnimalsCell DifferentiationCell LineageCRISPR-Cas SystemsMiceMice, Inbred C57BLMice, KnockoutT-bet Transcription FactorKlf2 protein, mouseKruppel-Like Transcription FactorsT-bet Transcription Factor
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.