SynthesisPloS one2025
The effectiveness and safety of physical activity and exercise on women with endometriosis: A systematic review and meta-analysis.
Synthesis in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Exploring the exercise dose to induce symptomatic and biomarker change in endometriosis: A protocol for a randomised controlled trial.MethodsX · 2026Article
- Lifestyle factors and symptom burden in endometriosis: an exploratory mixed-methods analysis of nutrition, physical activity, and psychosocial well-being.BMC women's health · 2026Article
- Oocyte quality in endometriosis-associated infertility: a narrative analysis of mechanisms and therapeutic options.Molecular biology reports · 2026Review
- Endometriosis: Epidemiology, Risk Factors, Molecular Mechanisms, Diagnosis, and Management.MedComm · 2026Review
- Management of bowel dysfunction after pelvic surgery for endometriosis.International journal of colorectal disease · 2026Review
- Physical Activity, Metabolic Dysfunction, and the Kynurenine Pathway in Endometriosis and Polycystic Ovary Syndrome: A Literature Review.Biomolecules · 2026Review
- Endometriosis and eating disorders: epidemiology, shared neurobiology, and clinical implications.Archives of gynecology and obstetrics · 2026Review
- Comparative Effectiveness of Non-Pharmacological Interventions for Pain and Quality of Life in Women with Endometriosis: A Systematic Review and Network Meta-Analysis.Journal of pain research · 2026Review
- Review
- Endometriosis: new insights and opportunities for relief of symptoms.Biology of reproduction · 2025Review
- Designing and validating a health promotion program for women with endometriosis: a mixed-methods study protocol.Frontiers in reproductive health · 2025Article
- Yearning for movement. A qualitative interview study exploring physical activity in the context of endometriosis-associated chronic pain.Women's health (London, England)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometriosis is a debilitating, chronic disease that affects approximately 10% of women of reproductive age worldwide. The most common symptom is chronic pelvic pain, which leads to a reduced quality of life and requires lifelong treatment. The current standard of care for endometriosis is pain management, which consists mainly of medical and surgical treatment. Appropriate physical activity (PA) and exercise can help manage both physical and psychological symptoms of chronic conditions. Consequently, this systematic review and meta-analysis was designed to assess the effectiveness and safety of PA and exercise in women with endometriosis.
methodsWe searched the published literature in Pubmed, Medline, Embase, The Cochrane Library, and Web of Science. Randomized controlled trials (RCTs) were obtained to assess the effects of physical activity and exercise on women with endometriosis. The random or fixed effects model was used to analyze the data in meta-analysis. The results were expressed as weighted mean differences (WMD) and their corresponding 95% confidence intervals (CIs).
resultsSix RCTs were identified in our systematic review, involving 251 patients. The results indicated that physical activity and exercise have a beneficial impact on quality of life, pain intensity, mental health, pelvic floor dysfunction, and bone density. However, due to the heterogeneity of the outcome measures and the incomplete reporting of the results in the studies included in this review, only a simple meta-analysis of two studies could be performed. The meta-analysis demonstrated that physical activity and exercise have a significant impact on the improvement of quality of life, particularly in the context of pain (P <0.0001), control and powerlessness (P <0.00001), and emotional well-being (P = 0.006).
conclusionThe present review indicates that physical activity and exercise have beneficial effects on the treatment of symptoms associated with endometriosis, particularly in terms of improving quality of life and providing pain relief. Due to the limitation in the quality of involved studies and the short duration of treatment, more RCTs with high-quality, long-term duration are needed for further validation.
trial registrationSystematic review registration: Registration number: CRD 42024547551.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.