Evidence map›Paper›PMID 39946318›Full record

ArticlePloS one2025

Protective effects of Colla Corii Asini Collagen Peptides on D-galactose injection combined with UVB irradiation-induced aging in mice.

Qingdi Luo, Song Zhang, Zhuo Sun, Zhihao Wang, Qiulin Yue, Xin Sun, Li Tian, Baojun Li, Kunlun Li, Chen Zhao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qingdi LuoState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Song ZhangState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Zhuo SunState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Zhihao WangState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Qiulin YueState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Xin SunState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Li TianState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.
Baojun LiJinan Hangchen Biotechnoogy Co., Ltd., Jinan, P.R. China.
Kunlun LiJinan Hangchen Biotechnoogy Co., Ltd., Jinan, P.R. China.
Chen ZhaoJinan Hangchen Biotechnoogy Co., Ltd., Jinan, P.R. China.
Lin ZhaoState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.ORCID https://orcid.org/0000-0002-4016-3176
Le SuState Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Shandong Academy of Sciences, Qilu University of Technology, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skin aging, autonomic mobility, memory function and physical deterioration are important features of aging, and effective anti-aging treatments are important in slowing down these processes. The objective of this research was to evaluate the protective effect of Colla Corii Asini (Ejiao) Collagen Peptides (CCACPs) on D-galactose (D-gal) injection combined with UV irradiation-induced senescence in mice. BY-HEALTH collagen oral solution (Bcos) was used as a positive control. Behavioural experiments showed that CCACPs significantly improved voluntary activity, learning memory and exercise endurance in aging mice. Elisa results showed that CCACPs reduced the levels of matrix metalloproteinase-1 (MMP-1) and MMP-3 in the skin, acetylcholinesterase (AChE) in the brain, and alanine aminotransferase (ALT) and azelaic aminotransferase (AST) in the liver of mice, while increasing the levels of collagen I in the skin and SOD in the brain. RT-qPCR revealed that CCACPs reduced the expression of p16, p19 and p21 genes in the liver and hippocampus, as well as the expression of IL-6 in the skin. Histological analysis of brain hippocampus, liver and skin confirmed the protective effects of CCACPs. The findings indicated that CCACPs may potentially slow the aging effects caused by D-galactose and UVB exposure in mice by reducing cellular senescence and oxidative stress levels. The results of this research provide the scientific basis for continuing to advance the extraction of collagen peptides from Colla Corii Asini as a potential anti-aging therapy.

Indexed as

AgingCollagenGalactosePeptidesSkin AgingUltraviolet RaysAcetylcholinesteraseAnimalsLiverMaleMatrix Metalloproteinase 1MiceOxidative StressSkinAcetylcholinesteraseCollagenGalactoseMatrix Metalloproteinase 1Peptides

Identifiers

PMID39946318
PMCPMC11825052

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.