Evidence map›Paper›PMID 39946202›Full record

ArticleAnnals of medicine2025

Comparison of effect and mechanism between nalfurafine hydrochloride and narrow-band ultraviolet B phototherapy in the treatment of pruritus in hemodialysis patients.

Sooyeon Choi, Dong Hui Shin, Jae-Seok Kim, Jun Young Lee, Seung Ok Choi, Byoung-Geun Han, Eun Jung Kim, Eung-Ho Choi, Jae Won Yang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sooyeon ChoiDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Dong Hui ShinDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Jae-Seok KimDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Jun Young LeeDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.ORCID 0000-0001-8047-4190
Seung Ok ChoiDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Byoung-Geun HanDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.
Eun Jung KimDepartment of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, South Korea.
Eung-Ho ChoiDepartment of Dermatology, Yonsei University, Wonju College of Medicine, Wonju, South Korea.
Jae Won YangDivision of Nephrology, Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPruritus in hemodialysis patients (HDP) is one of the serious complications associated with the quality of life and psychiatric disorder of patients. The narrowband ultraviolet B phototherapy (NB-UVB) treatment showed a statistically significant reduction of itching when performed more than 4 times compared to conservative treatment for itching, and the difference was confirmed to increase with repetition. We aim to compare newly developed Nalfuranfine HCL, kappa-opioid receptor agonist, with NB-UVB in HDP.

methodsTwenty HDP were enrolled from Wonju severance Christian hospital. Visual analog scale (VAS) score, Shiratori score, skin inflammatory cytokine levels, and blood calcium/phosphate/vitamin D levels were measured before four weeks of treatment, during four weeks of treatment, and after four weeks of treatment.

resultsVAS and Shiratori score was reduced in both nalfurafine and NB-UVB treatment groups significantly. After four weeks of treatment, the NB-UVB treatment group maintained a low Shiratori score, however, the Shiratori score increased in nalfurafine treatment group. Calcium phosphate product concentration was increased in the UVB treatment group and decreased in the nalfurafine treatment group. Vitamin D level was increased only in the UVB treatment group. Skin inflammatory cytokines levels showed a decreasing trend in both groups but not statistically significant. There were no side effects in both treatment groups.

conclusionsNalfurafine could be an alternative treatment option compared with NB-UVB as an oral medication in pruritis in hemodialysis patients, especially those with hyperphosphatemia.

Indexed as

MorphinansPruritusRenal DialysisSpiro CompoundsUltraviolet TherapyAdultAgedCalciumFemaleHumansMaleMiddle AgedQuality of LifeReceptors, Opioid, kappaTreatment OutcomeVitamin DCalciumMorphinansReceptors, Opioid, kappaSpiro CompoundsTRK 820Vitamin DHemodialysishyperphosphatemianalfurafineNB-UVBpruritis

Identifiers

PMID39946202
PMCPMC11827036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.