Evidence map›Paper›PMID 39946001›Full record

ReviewMolecular neurobiology2025

The Application of MicroRNAs in Traumatic Brain Injury: Mechanism Elucidation and Clinical Translation.

Hong Wang, Xiaolin Fan, Yuhao Zhang, Ning Ma, Liang Li, Qing Lu, Qi Wang, Boya Yu, Xiao Li, Junhong Gao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hong WangXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China. wanghong@mail.nwpu.edu.cn.
Xiaolin FanXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Yuhao ZhangXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Ning MaXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Liang LiXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Qing LuXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Qi WangXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Boya YuXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Xiao LiXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China.
Junhong GaoXi'an Key Laboratory of Toxicology and Biological Effects, Research Center for Toxicology and Biological Effects, Institute for Hygiene of Ordnance Industry, Xi'an, Shaanxi, 710065, China. gaoxing2285@126.com.

Funding

Natural Science Basis Research Plan in Shaanxi Province of China 2023-JC-QN-0983Natural Science Basis Research Plan in Shaanxi Province of China 2023-JC-YB-684
6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a complex neurological disease caused by external forces impacting the head and is one of the leading causes of mortality and disability worldwide, exerting a significant impact on public health and socioeconomic conditions. Current research on TBI has focused primarily on assessing injury severity, determining clinical treatment, and improving patient prognosis. The timely and accurate diagnosis of TBI in clinical settings and the implementation of effective therapeutic strategies remain challenging. However, a deeper understanding of changes in gene expression and underlying molecular regulatory processes may alleviate this pressing issue. MicroRNAs (miRNAs), a class of short noncoding RNA molecules, play crucial roles in cellular physiology and pathology by regulating gene expression. With advancements in research, miRNAs have garnered increasing attention in TBI studies. This review summarizes the progress of miRNA research in TBI and explores the potential of miRNAs as diagnostic and prognostic markers and therapeutic targets for TBI.

Indexed as

Brain Injuries, TraumaticMicroRNAsTranslational Research, BiomedicalAnimalsGene Expression RegulationHumansMicroRNAsBiomarkerMicroRNANeuroinflammationNeuronal apoptosisTraumatic brain injury

Identifiers

PMID39946001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.