Evidence map›Paper›PMID 39945978›Full record

ReviewHeart failure reviews2025

Tricuspid regurgitation after heart transplantation: where innovation and intervention are in hibernation.

Emyal Alyaydin, Alexander Gotschy, Danaë Parianos, Matthias P Nägele, Igor Tudorache, Andreas J Flammer, Julia Stehli

Abstract readReview
In one paragraph

Review in Heart failure reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emyal AlyaydinDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland. Emyal.Alyaydin@usz.ch.
Alexander GotschyDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Danaë ParianosDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Matthias P NägeleDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Igor TudoracheClinic for Cardiac Surgery, University Heart Center Zurich, Zurich, Switzerland.
Andreas J FlammerDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.
Julia StehliDepartment of Cardiology, University Hospital Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tricuspid regurgitation (TR) is a common valvular dysfunction following heart transplantation (HT), with reported prevalence rates ranging from 19 to 84%, primarily depending on the duration of follow-up. Its etiology is multifactorial and includes surgical technique, ischemic time, primary graft dysfunction, pulmonary hypertension, pacemaker leads, and endomyocardial biopsies. Severe TR can significantly impair graft function, exercise capacity, and patient survival. This mini-review explores current management strategies, including surgical techniques such as annuloplasty and tricuspid valve replacement. HT patients are often high-risk surgical candidates due to factors such as immunosuppressive therapy, prior surgeries, and various comorbidities. Therefore, we primarily focus on the evidence regarding emerging interventional methods, such as transcatheter edge-to-edge repair. Although these interventions show promising early results, they remain relatively novel in HT recipients, and the current evidence is based on case reports and small studies. Further research is essential to evaluate the long-term efficacy and safety of these management strategies to enhance outcomes for HT recipients with TR.

Indexed as

Cardiac Valve AnnuloplastyHeart TransplantationHeart Valve Prosthesis ImplantationPostoperative ComplicationsTricuspid ValveTricuspid Valve InsufficiencyHumansHeart transplantationHeart valve prosthesis implantationTranscatheter edge-to-edge repairTricuspid regurgitation

Identifiers

PMID39945978
PMCPMC11991953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.