Evidence map›Paper›PMID 39945970›Full record

ArticleDiscover nano2025

Eco-friendly synthesis of ZnO, CuO, and ZnO/CuO nanoparticles using extract of spent Pleurotus ostreatus substrate, and their antioxidant and anticancer activities.

Simangele Ngwenya, Nkanyiso J Sithole, Khosi Ramachela, Doctor M N Mthiyane, Mulunda Mwanza, Moganavelli Singh, Damian C Onwudiwe

Abstract read
In one paragraph

Article in Discover nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Biogenic ZnO-CuO Nanocomposites Synthesised UsingNanomaterials (Basel, Switzerland) · 2026
    Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simangele NgwenyaCrop Science Department, Faculty of Natural and Agricultural Science, North-West University, Mmabatho, 2035, South Africa.
Nkanyiso J SitholeCrop Science Department, Faculty of Natural and Agricultural Science, North-West University, Mmabatho, 2035, South Africa.
Khosi RamachelaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, 2735, South Africa.
Doctor M N MthiyaneFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, 2735, South Africa.
Mulunda MwanzaFood Security and Safety Focus Area, Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, 2735, South Africa.
Moganavelli SinghNano-Gene and Drug Delivery Laboratory, Department of Biochemistry, University of KwaZulu-Natal, Durban, 4000, South Africa.
Damian C OnwudiweMaterial Science Innovation and Modelling (MaSIM), Faculty of Natural and Agricultural Sciences, North-West University, Mmabatho, South Africa. Damian.Onwudiwe@nwu.ac.za.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosynthesis techniques for nanomaterials have advanced significantly, promoting eco-friendly synthesis chemistry as a sustainable alternative to conventional methods. This study presents a novel and environmentally friendly approach for synthesizing nanoparticulate ZnO, CuO, and ZnO/CuO nanocomposites using aqueous extracts of Pleurotus ostreatus spent substrate, is reported. The structural, optical, and morphological properties of the synthesized NPs were analysed. A hexagonal phase of ZnO NPs and a monoclinic phase of CuO NPs were obtained according to the X-ray diffraction analysis. A reduction in the peak intensity of these metal oxides was observed in the ZnO/CuO NPs due to reduced crystallinity. The absorption spectra, obtained from the UV-vis analysis, showed peaks at 354, 365, and 525 nm for the ZnO, CuO, and ZnO/CuO NPs, respectively. An anticancer assay of the NPs was conducted using human embryonic kidney (HEK 293) and cervical carcinoma (HeLa) cell lines, while a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay was used for the antioxidant evaluation. The ZnO, CuO, and ZnO/CuO NPs showed higher antioxidant potency with IC

Indexed as

Biological assaysBiomedicalGreen synthesisMetal oxidesPlant extracts

Identifiers

PMID39945970
PMCPMC11825426

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.